1: 2-((4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzo-[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)acetic acid With N-ethyl-N,N-diisopropylamine; HATU in tetrahydrofuran T=20°C; 3 h; 2: ethylamine in tetrahydrofuran 48 h;