1: With sulfuric acid in methanol 16 h; Reflux; 2: With sodium hydroxide in methanol pH=10 - 12; 2 h; 3: With hydrogenchloride in methanol; water pH=4.5;
参考文献
Ghislieri, Diego; Green, Anthony P.; Pontini, Marta; Willies, Simon C.; Rowles, Ian; Frank, Annika; Grogan, Gideon; Turner, Nicholas J.
Journal of the American Chemical Society, 2013 , vol. 135, # 29 p. 10863 - 10869
1: C19H23ClN2O*ClH With ammonia in water; toluene pH=8.5 - 9; 0.25 h; 2: sodium salt of the chloroacetic acid With potassium hydroxide in N,N-dimethyl-formamide T=0 - 10°C; 3: With hydrogenchloride in dichloromethane; water pH=4.3 - 4.8;
