2-[4-[(E)-1,2-二苯基丁-1-烯基]苯氧基]-N,N-二甲基-乙胺合成路线 （共 46 条）
反应条件
in N,N-dimethyl-formamide T=50°C; 0.5 h;
参考文献
Tetrahedron Letters, , vol. 45, # 5 p. 965 - 967
反应条件
1: (1-phenylpropyl)phosphonic acid di-o-tolyl ester With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: 4-[2-(dimethylamino)ethoxy]benzophenone in tetrahydrofuran; hexane T=-78°C; Horner reaction; 48 h;
参考文献
Synthetic Communications, , vol. 35, # 21 p. 2795 - 2800
反应条件
1: Pd 2: 90 percent / NaSEt / dimethylformamide / 10 h / Heating 3: 1.) H+, 2.) NaOMe View Scheme
参考文献
Synthetic Communications, , vol. 17, # 10 p. 1247 - 1252
反应条件
1: Pd 2: 90 percent / NaSEt / dimethylformamide / 10 h / Heating 3: 1.) H+, 2.) NaOMe View Scheme
参考文献
Synthetic Communications, , vol. 17, # 10 p. 1247 - 1252
反应条件
1: 98 percent / BBr3 / CH2Cl2 / 2 h / -78 °C 2: 44 percent / dimethylformamide / 0.5 h / 50 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 5 p. 965 - 967
反应条件
1: aq. H2O2; N2H4*H2O / ethanol; CH2Cl2 / -60 - 20 °C 2: BBr3 / CH2Cl2 / 5 h / -60 - 20 °C 3: EtONa / ethanol / 24 h / Heating View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 10 p. 1828 - 1831
反应条件
2,2'-bis(di-p-tolyl-phosphino)-1,1'-binaphthyl; palladium diacetate; zinc(II) chloride in tetrahydrofuran; hexane T=25°C; Negishi coupling reaction; 18 h; optical yield given as percent de;
参考文献
Synthesis, , # 16 p. 2761 - 2765
反应条件
n-butyllithium; triethylamine; trifluoroacetic anhydride in tetrahydrofuran; hexane T=-50 - 100°C; 1.33333 h; Inert atmosphereFlow reactor; Overall yield = 84 percent; Overall yield = 12.43 g;
参考文献
Organic Process Research and Development, , vol. 17, # 9 p. 1192 - 1208
反应条件
Pd0(tris(tert-butyl)phosphine)2; sodium hydroxide in tetrahydrofuran; water T=60°C; Suzuki-Miyaura Coupling; Overall yield = 80 percent; chemoselective reaction;
参考文献
Chemical Science, , vol. 5, # 2 p. 694 - 698
反应条件
sodium hydroxide; Pd0(tris(tert-butyl)phosphine)2 in tetrahydrofuran T=60°C; Suzuki-Miyaura coupling; 24 h; Product distribution; Further Variations:Reagents;
参考文献
Advanced Synthesis and Catalysis, , vol. 346, # 13-15 p. 1824 - 1835
