2-[4-[(E)-1,2-二苯基丁-1-烯基]苯氧基]-N,N-二甲基-乙胺合成路线 （共 46 条）
反应条件
1: hafnium tetrachloride; trimethylsilyl trifluoromethanesulfonate / 2 h / 20 °C 2: 96 percent / t-BuOK / dimethylsulfoxide / 0.25 h / 20 °C 3: 98 percent / BBr3 / CH2Cl2 / 2 h / -78 °C 4: 44 percent / dimethylformamide / 0.5 h / 50 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 5 p. 965 - 967
反应条件
1: 96 percent / t-BuOK / dimethylsulfoxide / 0.25 h / 20 °C 2: 98 percent / BBr3 / CH2Cl2 / 2 h / -78 °C 3: 44 percent / dimethylformamide / 0.5 h / 50 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 5 p. 965 - 967
反应条件
1: 90 percent / NaSEt / dimethylformamide / 10 h / Heating 2: 1.) H+, 2.) NaOMe View Scheme
参考文献
Synthetic Communications, , vol. 17, # 10 p. 1247 - 1252
反应条件
sodium ethanolate in ethanol 24 h; Heating; Title compound not separated from byproducts;
参考文献
Organic and Biomolecular Chemistry, , vol. 3, # 10 p. 1828 - 1831
反应条件
2: cc. HCl / ethanol / 0.33 h / Heating 3: cc. HCl / ethanol / 4 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1011 - 1016
反应条件
hydrogenchloride in ethanol 4 h; Heating;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1011 - 1016
反应条件
1.1: 95 percent / PBr3 / CH2Cl2 / 20 °C 2.1: 120 h / 130 °C 2.2: 45 percent / NaOH / H2O / 20 °C 3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C 3.2: 12 percent / tetrahydrofuran; hexane / 48 h / -78 °C View Scheme
参考文献
Synthetic Communications, , vol. 35, # 21 p. 2795 - 2800
反应条件
1.1: 120 h / 130 °C 1.2: 45 percent / NaOH / H2O / 20 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C 2.2: 12 percent / tetrahydrofuran; hexane / 48 h / -78 °C View Scheme
参考文献
Synthetic Communications, , vol. 35, # 21 p. 2795 - 2800
反应条件
1.1: 90 percent / sodium ethoxide / ethanol / 24 h / Heating 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C 2.2: 12 percent / tetrahydrofuran; hexane / 48 h / -78 °C View Scheme
参考文献
Synthetic Communications, , vol. 35, # 21 p. 2795 - 2800
反应条件
1: 1.) Mg, BrCH2CH2Br, I2 / 1.) Et2O, reflux, 1 h, 2.) 16 h 2: conc. HCl / ethanol / 2 h / Heating 3: 88 percent / CH3ONa / dimethylformamide / 2 h / 35 °C 4: 1.) NaH / 1.) DMF, 2.) 60 deg C, 30 min View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 4 p. 1342 - 1388
