3-(2-氯乙基)-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮合成路线 （共 12 条）
反应条件
N-ethyl-N,N-diisopropylamine in methanol T=20°C; HeatingReflux; Product distribution / selectivity;
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; SATYANARAYANA, Revu
Patent: WO2010/4578 A2, 2010 ;
Location in patent: Page/Page column 10; 18 ;
反应条件
1: triethylamine; dimethyl sulfoxide / dichloromethane 2: methanol View Scheme
参考文献
MSN Laboratories Limited; Reddy, Manne Satyanarayana; Eswaraiah, Sajja; Satyanarayana, Revu
Patent: US8481729 B2, 2013 ;
反应条件
N-ethyl-N,N-diisopropylamine in methanol T=50 - 70°C;
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PATEL, Dhimant, Jasubhai; ROY, Rushikesh, Udaykumar; PATEL, Mayur, Ramnikbhai
Patent: WO2011/73997 A2, 2011 ;
Location in patent: Page/Page column 15 ;
反应条件
N-ethyl-N,N-diisopropylamine in methanol 24 h; Reflux;
参考文献
Laboratorios Lesvi, S.L.
Patent: EP2202234 A1, 2010 ;
Location in patent: Page/Page column 7 ;
反应条件
diisopropylamine in methanol T=55 - 60°C; 12 h;
参考文献
GLENMARK GENERICS LIMITED
Patent: WO2009/130710 A2, 2009 ;
Location in patent: Page/Page column 15 ;
反应条件
in methanol; water; acetone
参考文献
Padi, Pratap Reddy; Bollikonda, Satyanarayana; Akundi, Surya Prabhakar; Cherukupally, Praveen; Suthrapu, Sashikanth; Mohanarangam, Saravanan; Kandirelli, Venkat Kiran; Chellu, Malleswara Rao; Pagadala, Narasimha Rao
Patent: US2009/48272 A1, 2009 ;
反应条件
N-ethyl-N,N-diisopropylamine in methanol T=20°C; HeatingReflux; Product distribution / selectivity;
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; SATYANARAYANA, Revu
Patent: WO2010/4578 A2, 2010 ;
Location in patent: Page/Page column 10; 18 ;
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0.25 h / 25 - 30 °C 1.2: 2 h / 25 - 40 °C 2.1: potassium carbonate / acetonitrile / 1.17 h / 25 - 60 °C 2.2: 14 h / 20 - 75 °C 3.1: hydrogenchloride / water / 2 h / 75 - 80 °C 3.2: 1 h / 10 - 30 °C / pH 10 - 12 / Reflux View Scheme
参考文献
Davuluri, Ramamohan Rao; Ponnaiah, Ravi; Neela, Praveen Kumar; Batthini, Guruswamy; Venkata Narasimharao, Telagareddy; Ravanababu, Kosireddy; Sudheer, Kallepally
Patent: US2014/73787 A1, 2014 ;
参考文献
MSN LABORATORIES LIMITED
Patent: US2011/293889 A1, 2011 ;
反应条件
1: triethylamine; dimethyl sulfoxide / dichloromethane 2: methanol 3: sodium borohydride / dichloromethane; methanol View Scheme
参考文献
MSN LABORATORIES LIMITED
Patent: US2011/293889 A1, 2011 ;
