[Ru(N,N-bis[(pyridin-2-yl)methyl][2-(diphenylphosphino)phenyl]methanamine)(CH3COO)][BPh4] in tetrahydrofuran T=80°C; 1 h; Inert atmosphere;

1: 90.6 percent / NaOMe / methanol / 1.) 1 h, -10 deg C, 2.) 16 h, room temperature 2: 86.4 percent / aq. KOH / ethanol / 1 h 3: 52.4 percent / Heating 4: 76.7 percent / p-TsOH / benzene / 4 h / Heating 5: 1.) n-BuLi / 1.) THF, hexane, -82 deg C, 1 h, 2.) THF, 2 h 6: 26 percent / 0.2 N aq. HCl / dioxane / 48 h / Heating View Scheme

1: 93.2 percent / p-TsOH / 65 h / Heating 2: 1.) n-BuLi / 1.) THF, hexane, 1 h, -78 deg C, 2.a) THF, 2 h, -78 deg C, 2.b) 30 min, room temperature 3: 41.6 percent / 0.2 N aq. HCl / dioxane / 90 h / Ambient temperature 4: 54.3 percent / NEt3, methansulfonsaeurechlorid / CH2Cl2 / 3 h / temperature < 15 deg C View Scheme

methanesulfonyl chloride; triethylamine in dichloromethane 3 h; temperature < 15 deg C;

1: 76.7 percent / p-TsOH / benzene / 4 h / Heating 2: 1.) n-BuLi / 1.) THF, hexane, -82 deg C, 1 h, 2.) THF, 2 h 3: 26 percent / 0.2 N aq. HCl / dioxane / 48 h / Heating View Scheme

1: 1.) n-BuLi / 1.) THF, hexane, -82 deg C, 1 h, 2.) THF, 2 h 2: 26 percent / 0.2 N aq. HCl / dioxane / 48 h / Heating View Scheme

1: 1.) n-BuLi / 1.) THF, hexane, 1 h, -78 deg C, 2.a) THF, 2 h, -78 deg C, 2.b) 30 min, room temperature 2: 41.6 percent / 0.2 N aq. HCl / dioxane / 90 h / Ambient temperature 3: 54.3 percent / NEt3, methansulfonsaeurechlorid / CH2Cl2 / 3 h / temperature < 15 deg C View Scheme

1: 41.6 percent / 0.2 N aq. HCl / dioxane / 90 h / Ambient temperature 2: 54.3 percent / NEt3, methansulfonsaeurechlorid / CH2Cl2 / 3 h / temperature < 15 deg C View Scheme