2-氯-3-溴-5-羟基吡啶合成路线

Smith, Adrian L.; D'Angelo, Noel D.; Bo, Yunxin Y.; Booker, Shon K.; Cee, Victor J.; Herberich, Brad; Hong, Fang-Tsao; Jackson, Claire L. M.; Lanman, Brian A.; Liu, Longbin; Nishimura, Nobuko; Pettus, Liping H.; Reed, Anthony B.; Tadesse, Seifu; Tamayo, Nuria A.; Wurz, Ryan P.; Yang, Kevin; Andrews, Kristin L.; Whittington, Douglas A.; McCarter, John D.; Miguel, Tisha San; Zalameda, Leeanne; Jiang, Jian; Subramanian, Raju; Mullady, Erin L.; Caenepeel, Sean; Freeman, Daniel J.; Wang, Ling; Zhang, Nancy; Wu, Tian; Hughes, Paul E.; Norman, Mark H.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 11 p. 5188 - 5219

130115-85-42-氯-3-溴-5-羟基吡啶+

74-88-4甲基碘

1033202-44-63-溴-2-氯-5-甲氧基吡啶

参考文献

Smith, Adrian L.; D'Angelo, Noel D.; Bo, Yunxin Y.; Booker, Shon K.; Cee, Victor J.; Herberich, Brad; Hong, Fang-Tsao; Jackson, Claire L. M.; Lanman, Brian A.; Liu, Longbin; Nishimura, Nobuko; Pettus, Liping H.; Reed, Anthony B.; Tadesse, Seifu; Tamayo, Nuria A.; Wurz, Ryan P.; Yang, Kevin; Andrews, Kristin L.; Whittington, Douglas A.; McCarter, John D.; Miguel, Tisha San; Zalameda, Leeanne; Jiang, Jian; Subramanian, Raju; Mullady, Erin L.; Caenepeel, Sean; Freeman, Daniel J.; Wang, Ling; Zhang, Nancy; Wu, Tian; Hughes, Paul E.; Norman, Mark H.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 11 p. 5188 - 5219

864771-17-53-甲基-1H-吲唑-5-硼酸频哪醇酯+

130115-85-42-氯-3-溴-5-羟基吡啶

864771-15-3

参考文献

SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/85227 A1, 2005 ;
Location in patent: Page/Page column 38; 81 ;
WO 2005/085227 A1