3,6-二溴吡嗪-2-羧酰胺合成路线 （共 4 条）
反应条件
1: With hydrogen bromide; bromine in acetic acid T=-10°C; 0.75 h; 2: With sodium nitrite in water T=-10 - -5°C; 2.5 h;
参考文献
WIGERINCK, Piet Tom Bert Paul; ANDREWS, Martin James Inglis; De WEER, Marc Maurice Germain; SABOURAULT, Nicholas Luc; KLUGE, Stefan Christian
Patent: US2011/118269 A1, 2011 ;
Location in patent: Page/Page column 13-14 ;
反应条件
1.1: sodium acetate; bromine; acetic acid / 2 h / 50 - 55 °C 2.1: bromine; hydrogen bromide / acetic acid / 0.75 h / -10 °C 2.2: 2.5 h / -10 - -5 °C View Scheme
参考文献
WIGERINCK, Piet Tom Bert Paul; ANDREWS, Martin James Inglis; De WEER, Marc Maurice Germain; SABOURAULT, Nicholas Luc; KLUGE, Stefan Christian
Patent: US2011/118269 A1, 2011 ;
反应条件
1.1: ammonia / water; methanol / 24 h / 30 °C 2.1: sodium acetate; bromine; acetic acid / 2 h / 50 - 55 °C 3.1: bromine; hydrogen bromide / acetic acid / 0.75 h / -10 °C 3.2: 2.5 h / -10 - -5 °C View Scheme
参考文献
WIGERINCK, Piet Tom Bert Paul; ANDREWS, Martin James Inglis; De WEER, Marc Maurice Germain; SABOURAULT, Nicholas Luc; KLUGE, Stefan Christian
Patent: US2011/118269 A1, 2011 ;
反应条件
bromine; potassium hydroxide in water T=-5 - 15°C; 1.08333 h;
参考文献
WIGERINCK, Piet Tom Bert Paul; ANDREWS, Martin James Inglis; De WEER, Marc Maurice Germain; SABOURAULT, Nicholas Luc; KLUGE, Stefan Christian
Patent: US2011/118269 A1, 2011 ;
Location in patent: Page/Page column 14 ;
