反应条件
1: 95 percent / Amberlist15 / CH2Cl2 / 6 h / Ambient temperature
2: 1.) O3, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2, from -78 deg C to RT
3: 1.) n-BuLi / 1.) THF, hexane, RT, 15 min, 2.) THF, hexane, RT, 18 h
4: 91 percent / H2 / 10percent Pd/C / ethanol / 12 h
5: 94 percent / p-toluenesulfonic acid, H2O / tetrahydrofuran / 18 h / Ambient temperature
6: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 1 h, 2.) CH2Cl2, 0 deg C, 20 min
7: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, 1 h
8: 91 percent / ethanethiol, NaH / dimethylformamide / 3 h / Heating
9: 62.7 percent / salcomine, O2 / dimethylformamide / 14 h
View Scheme
参考文献
Fukuyama; Kiriyama; Okino; Kodama; Iwaki; Hosozawa; Matsui
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 3 p. 561 - 565
