(S)-3-苯基-3-(4-三氟甲基-苯氧基)-丙胺盐酸盐合成路线 （共 13 条）
反应条件
1: (1R)-3-amino-1-phenyl-1-propanol With sodium hydride in dimethyl sulfoxide T=55°C; 0.5 h; 2: 1-chloro-4-(trifluoromethyl)benzene in dimethyl sulfoxide T=90°C; 1 h;
参考文献
Kumar, Pradeep; Upadhyay, Rajesh Kumar; Pandey, Rajesh Kumar
Tetrahedron Asymmetry, 2004 , vol. 15, # 24 p. 3955 - 3959
反应条件
sodium hydride in N,N-dimethyl-formamide T=20°C; Resolution of racemate;
参考文献
HUMAN BIOMOLECULAR RESEARCH INSTITUTE
Patent: WO2006/25920 A2, 2006 ;
Location in patent: Page/Page column 148-149 ;
WO 2006/025920 A2
反应条件
in dimethyl sulfoxide T=90°C; 2 h;
参考文献
AMPLA PHARMACEUTICALS INC.
Patent: WO2009/73138 A2, 2009 ;
Location in patent: Page/Page column 83-85 ;
WO 2009/073138 A2
反应条件
1: 99 percent / potassium ferricyanide; potassium carbonate; osmium tetroxide / (DHQ)2PHAL / H2O; 2-methyl-propan-2-ol; toluene / 24 h / 0 °C 2: 99 percent / dibutyltin oxide; triethylamine / CH2Cl2 / 0.75 h / 20 °C 3: 90 percent / ethanol; H2O / 24 h / 20 °C 4: 96 percent / borane dimethyl sulfide complex; methyl sulfide / tetrahydrofuran / 2.5 h / Heating 5: 90 percent / sodium hydride / dimethylsulfoxide / 55 - 90 °C View Scheme
参考文献
Pandey, Rajesh Kumar; Fernandes, Rodney A.; Kumar, Pradeep
Tetrahedron Letters, 2002 , vol. 43, # 25 p. 4425 - 4426
反应条件
hydrazine hydrate in methanol; dichloromethane T=20°C; 8 h;
参考文献
Cashman, John R.; Voelker, Troy; Johnson, Robert; Janowsky, Aaron
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 337 - 343
反应条件
1: 99 percent / dibutyltin oxide; triethylamine / CH2Cl2 / 0.75 h / 20 °C 2: 90 percent / ethanol; H2O / 24 h / 20 °C 3: 96 percent / borane dimethyl sulfide complex; methyl sulfide / tetrahydrofuran / 2.5 h / Heating 4: 90 percent / sodium hydride / dimethylsulfoxide / 55 - 90 °C View Scheme
参考文献
Pandey, Rajesh Kumar; Fernandes, Rodney A.; Kumar, Pradeep
Tetrahedron Letters, 2002 , vol. 43, # 25 p. 4425 - 4426
反应条件
1: 96 percent / borane dimethyl sulfide complex; methyl sulfide / tetrahydrofuran / 2.5 h / Heating 2: 90 percent / sodium hydride / dimethylsulfoxide / 55 - 90 °C View Scheme
参考文献
Kamal, Ahmed; Khanna; Ramu
Tetrahedron Asymmetry, 2002 , vol. 13, # 18 p. 2039 - 2051
反应条件
1: 90 percent / ethanol; H2O / 24 h / 20 °C 2: 96 percent / borane dimethyl sulfide complex; methyl sulfide / tetrahydrofuran / 2.5 h / Heating 3: 90 percent / sodium hydride / dimethylsulfoxide / 55 - 90 °C View Scheme
参考文献
Pandey, Rajesh Kumar; Fernandes, Rodney A.; Kumar, Pradeep
Tetrahedron Letters, 2002 , vol. 43, # 25 p. 4425 - 4426
反应条件
1: 80 percent / ethanol; H2O / 20 °C 2: 46 percent / Pseudomonas cepacia lipase on modified ceramic particles / diisopropyl ether / 16 h / 27 °C 3: 88 percent / BH3*SMe2 / tetrahydrofuran / Heating 4: 68 percent / NaH / dimethylsulfoxide / 1 h / 90 - 100 °C View Scheme
参考文献
Kamal, Ahmed; Khanna; Ramu
Tetrahedron Asymmetry, 2002 , vol. 13, # 18 p. 2039 - 2051
反应条件
1: 88 percent / BH3*SMe2 / tetrahydrofuran / Heating 2: 68 percent / NaH / dimethylsulfoxide / 1 h / 90 - 100 °C View Scheme
参考文献
Kamal, Ahmed; Khanna; Ramu
Tetrahedron Asymmetry, 2002 , vol. 13, # 18 p. 2039 - 2051
