(S)-3-苯基-3-(4-三氟甲基-苯氧基)-丙胺盐酸盐合成路线 （共 13 条）
反应条件
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: sodium iodide / dimethyl sulfoxide / 13 h / 70 °C 3.1: hydrazine hydrate / methanol; dichloromethane / 8 h / 20 °C View Scheme
参考文献
Cashman, John R.; Voelker, Troy; Johnson, Robert; Janowsky, Aaron
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 337 - 343
反应条件
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: sodium iodide / dimethyl sulfoxide / 13 h / 70 °C 3.1: hydrazine hydrate / methanol; dichloromethane / 8 h / 20 °C View Scheme
参考文献
Cashman, John R.; Voelker, Troy; Johnson, Robert; Janowsky, Aaron
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 337 - 343
反应条件
1: aq. K2CO3 / CH2Cl2 / 0.5 h 2: LiAlH4 / tetrahydrofuran / 2 h / 65 °C 3: 95 percent / HCl / diethyl ether View Scheme
参考文献
Pandey, Rajesh Kumar; Fernandes, Rodney A.; Kumar, Pradeep
Tetrahedron Letters, 2002 , vol. 43, # 25 p. 4425 - 4426
