10-氨基-4-乙基-4-羟基-1H-吡喃并[3',4':6,7]吲哚嗪并[1,2-b]喹啉-3,14(4H,12H)-二酮合成路线 （共 6 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr; 20 h;
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
反应条件
1: 98 percent / p-TsOH*H2O / toluene / 4.5 h / Heating 2: 90 percent / Na2S*9H2O / ethanol; H2O / 0.5 h / Heating 3: 89 percent / 2N aq. H2SO4 / tetrahydrofuran / 1 h 4: 86 percent / conc. HCl, glacial AcOH / 4 h / Heating 5: 65 percent / H2 / 10percent Pd/C / ethanol / 20 h / 760 Torr View Scheme
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
反应条件
1: 86 percent / conc. HCl, glacial AcOH / 4 h / Heating 2: 65 percent / H2 / 10percent Pd/C / ethanol / 20 h / 760 Torr View Scheme
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
反应条件
1: 86 percent / conc. HCl, glacial AcOH / 4 h / Heating 2: 65 percent / H2 / 10percent Pd/C / ethanol / 20 h / 760 Torr View Scheme
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
反应条件
1: 89 percent / 2N aq. H2SO4 / tetrahydrofuran / 1 h 2: 86 percent / conc. HCl, glacial AcOH / 4 h / Heating 3: 65 percent / H2 / 10percent Pd/C / ethanol / 20 h / 760 Torr View Scheme
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
反应条件
1: 90 percent / Na2S*9H2O / ethanol; H2O / 0.5 h / Heating 2: 89 percent / 2N aq. H2SO4 / tetrahydrofuran / 1 h 3: 86 percent / conc. HCl, glacial AcOH / 4 h / Heating 4: 65 percent / H2 / 10percent Pd/C / ethanol / 20 h / 760 Torr View Scheme
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
