1-(2-氨基-1-(4-甲氧基苯基)乙基)环己醇盐酸盐合成路线 （共 9 条）
反应条件
hydrogenchloride; hydrogen; palladium 10 on activated carbon in methanol; ethanol T=20°C; P=2625.26 Torr; 6 h; Product distribution / selectivity;
参考文献
KRKA
Patent: WO2007/147564 A1, 2007 ;
Location in patent: Page/Page column 12 ;
反应条件
ammonium hydroxide; nickel monoaluminide in methanol; ethyl acetate
反应条件
hydrogenchloride in ethyl acetate; isopropyl alcohol T=5 - 10°C; 0.666667 - 1 h; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/47972 A2, 2007 ;
Location in patent: Page/Page column 20 ;
反应条件
1: With formic acid in water T=97 - 99°C; 16 h; 2: With hydrogenchloride in isopropyl alcohol T=10°C; pH=2.0; 1 - 2 h;
参考文献
Dishman Pharmaceuticals and Chemicals Ltd.
Patent: EP1721889 A1, 2006 ;
Location in patent: Page/Page column 6 ;
反应条件
1: With formic acid; hexamethylenetetramine in water T=20 - 102°C; 0.25 h; 2: With sodium hydroxide in water T=15 - 20°C; pH=10 - 11; Product distribution / selectivity;
参考文献
IND-SWIFT LABORATORIES LIMITED
Patent: WO2007/49302 A2, 2007 ;
Location in patent: Page/Page column 7-8 ;
反应条件
sodium hydroxide in methanol T=20°C; 0.25 h; Product distribution / selectivity;
参考文献
Niddam-Hildesheim, Valerie; Shenkar, Natalia; Shachan-Tov, Sharona
Patent: US2008/139849 A1, 2008 ;
Location in patent: Page/Page column 6 ;
反应条件
1: With sodium hydroxide; formaldehyd; formic acid in water T=20°C; 5 h; Heating / reflux; 2: With sodium hydroxide in water T=20°C; pH=12;
参考文献
IND-SWIFT LABORATORIES LIMITED
Patent: WO2007/49302 A2, 2007 ;
Location in patent: Page/Page column 9-10; 11-12 ;
反应条件
sodium hydroxide in water 20 - 24 h; Heating / reflux; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/47972 A2, 2007 ;
Location in patent: Page/Page column 21; 22 ;
反应条件
1: With sodium sulfide hydrate in 1-methyl-pyrrolidin-2-one T=20 - 185°C; 2: With succinic acid in 1-methyl-pyrrolidin-2-one; water T=10 - 90°C; pH=10 - 11;
参考文献
Niddam-Hildesheim, Valarie; Nidam, Tamar; Vollerner, Yuri; Adler, Miri; Kravitz, Miri; Shachan-tov, Sharona
Patent: US2009/234020 A1, 2009 ;
Location in patent: Page/Page column 6 ;
