反应条件
1: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 1 h, 2.) CH2Cl2, 0 deg C, 1 h 2: NaH / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) 0 deg C, 30 min 3: 87 percent / H2O / hexane; 1,2-dichloro-ethane / -30 °C 4: 2,6-lutidine / CH2Cl2 / 0.75 h 6: 93 percent / (R,R)-diisopropyl tartrate, 4 Angstroem molecular sieves / toluene / 1.) -78 deg C, 3 h, 2.) r.t., 12 h 7: TBAF / tetrahydrofuran / 0.5 h 8: TsOH / 0.25 h 9: 1.) catecholborane, 2.) H2O2, NaOH / 1.) (PPh3)3RhCl / 1.) THF, 45 min 10: 1.) (COCl)2, DMSO, 2.) Et3N 11: NaH / tetrahydrofuran / 4 h 12: H2 / 10percent Pd/C / ethanol; ethyl acetate / 5 h 13: tetrahydrofuran / 3 h 14: HCl, H2O / tetrahydrofuran / 3 h / 50 °C 15: 90 percent / TsOH / benzene / 0.5 h 16: 94 percent / 2,6-lutidine / CH2Cl2 / 4 h / -78 °C 17: 75 percent / DIBAL-H / CH2Cl2 / 1.5 h / -78 - -15 °C 18: 1.) (COCl)2, DMSO, 2.) Et3N 20: 2,6-lutidine / CH2Cl2 / 4 h / -50 °C 21: DDQ, H2O / CH2Cl2 / 3 h / 0 °C 22: Dess-Martin periodinane 23: Mo(CHMe2Ph)<N(2,6-(i-Pr)2C6H3)><OCMe(CF3)2>2 / benzene / 4 h / 55 °C 24: 60 percent / HF*pyridine / tetrahydrofuran / 3 h 25: 86 percent / dimethyldioxirane / CH2Cl2 / 4 h / -50 °C View Scheme
参考文献
May, Scott A.; Grieco, Paul A.
Chemical Communications, 1998 , # 15 p. 1597 - 1598
