7-溴-2,2-二甲基苯并二氢吡喃-4-酮合成路线 （共 4 条）
参考文献
Allergan Sales, Inc.
Patent: US6403638 B1, 2002 ;
US 6403638 B1
反应条件
piperidine in benzene 16 h; Heating;
参考文献
Buckle, Derek R.; Arch, Jonathon R. S.; Fenwick, Ashley E.; Houge-Frydrych, Catherine S. V.; Pinto, Ivan L.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3028 - 3034
反应条件
AlCl3, aluminium chloride
参考文献
Tsang, Kwok Yin; Sinha, Santosh; Liu, Xiaoxia; Bhat, Smita; Chandraratna, Roshantha A.
Patent: US2005/148590 A1, 2005 ;
Location in patent: Page/Page column 29 ;
反应条件
1: 61 percent / dimethylformamide / 24 h / Heating
2: 79 percent / KBH4 / methanol / 1.) 0 deg C, 30 min, 2.) RT, 30 min
3: 4-toluenesulfonic acid / toluene / 4.5 h / Heating
View Scheme
参考文献
Buckle, Derek R.; Arch, Jonathon R. S.; Fenwick, Ashley E.; Houge-Frydrych, Catherine S. V.; Pinto, Ivan L.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3028 - 3034
