1.1: sulfuric acid / water; methanol / 6 h / 20 °C 2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h 3.1: triethylamine; lithium chloride / tetrahydrofuran / 1.5 h / -10 °C / Inert atmosphere 3.2: 2.42 h / -10 °C / Inert atmosphere 4.1: B-chloro-diisopinocampheylborane / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere 5.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere 5.2: -78 - 20 °C 6.1: tetrabutyl ammonium fluoride / water; tetrahydrofuran / 4 h / 0 °C 7.1: triethylamine; hydrogen / platinum on carbon / methanol / 24.25 h / 20 °C 8.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere 8.2: -15 - -10 °C / Inert atmosphere 9.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 40 °C View Scheme

1.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere 2.1: sulfuric acid / methanol / 4 h / 20 °C / Inert atmosphere 3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h 4.1: triethylamine; lithium chloride / tetrahydrofuran / 1.5 h / -10 °C / Inert atmosphere 4.2: 2.42 h / -10 °C / Inert atmosphere 5.1: B-chloro-diisopinocampheylborane / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere 6.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere 6.2: -78 - 20 °C 7.1: tetrabutyl ammonium fluoride / water; tetrahydrofuran / 4 h / 0 °C 8.1: triethylamine; hydrogen / platinum on carbon / methanol / 24.25 h / 20 °C 9.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere 9.2: -15 - -10 °C / Inert atmosphere 10.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 40 °C View Scheme

1.1: sulfuric acid / methanol / 4 h / 20 °C / Inert atmosphere 2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h 3.1: triethylamine; lithium chloride / tetrahydrofuran / 1.5 h / -10 °C / Inert atmosphere 3.2: 2.42 h / -10 °C / Inert atmosphere 4.1: B-chloro-diisopinocampheylborane / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere 5.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere 5.2: -78 - 20 °C 6.1: tetrabutyl ammonium fluoride / water; tetrahydrofuran / 4 h / 0 °C 7.1: triethylamine; hydrogen / platinum on carbon / methanol / 24.25 h / 20 °C 8.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere 8.2: -15 - -10 °C / Inert atmosphere 9.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 40 °C View Scheme

1.1: B-chloro-diisopinocampheylborane / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere 2.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C 3.1: tetrabutyl ammonium fluoride / water; tetrahydrofuran / 4 h / 0 °C 4.1: triethylamine; hydrogen / platinum on carbon / methanol / 24.25 h / 20 °C 5.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere 5.2: -15 - -10 °C / Inert atmosphere 6.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 40 °C View Scheme

1.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere 1.2: -78 - 20 °C 2.1: tetrabutyl ammonium fluoride / water; tetrahydrofuran / 4 h / 0 °C 3.1: triethylamine; hydrogen / platinum on carbon / methanol / 24.25 h / 20 °C 4.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere 4.2: -15 - -10 °C / Inert atmosphere 5.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 40 °C View Scheme

1.1: tetrabutyl ammonium fluoride / water; tetrahydrofuran / 4 h / 0 °C 2.1: triethylamine; hydrogen / platinum on carbon / methanol / 24.25 h / 20 °C 3.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere 3.2: -15 - -10 °C / Inert atmosphere 4.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 40 °C View Scheme

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 20 °C / Inert atmosphere 2.1: tetrahydrofuran / -15 - -5 °C / Inert atmosphere 2.2: 15 - 30 °C View Scheme

1.1: diisobutylaluminium hydride / toluene / 1 h / -65 - -60 °C / Inert atmosphere 1.2: 1 h / 25 °C 2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere 2.2: 1.5 h / 25 °C / Inert atmosphere 2.3: pH 5 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 8 h / 25 °C / Inert atmosphere 4.1: sodium iodide; cerium(III) chloride heptahydrate / acetonitrile / 2 h / 80 - 85 °C View Scheme

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere 1.2: 1.5 h / 25 °C / Inert atmosphere 1.3: pH 5 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 8 h / 25 °C / Inert atmosphere 3.1: sodium iodide; cerium(III) chloride heptahydrate / acetonitrile / 2 h / 80 - 85 °C View Scheme

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetone / 8 h / 25 °C / Inert atmosphere 2: sodium iodide; cerium(III) chloride heptahydrate / acetonitrile / 2 h / 80 - 85 °C View Scheme