1-(4-甲氧基-联苯-4-基)-乙酮合成路线 （共 91 条）
反应条件
caesium carbonate; triphenylphosphine; palladium dichloride in N,N-dimethyl acetamide
T=90°C; 2 h;
参考文献
Rao, Maddali L.N.; Jadhav, Deepak N.; Banerjee, Debasis
Tetrahedron, 2008 , vol. 64, # 24 p. 5762 - 5772
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in water
T=80°C; Suzuki Coupling; 22 h;
参考文献
BASF SE; SCHMIDT-LEITHOFF, Joachim; PICHLMAIR, Stefan; BELLO, Charles; BASF (CHINA) COMPANY LIMITED
Patent: WO2013/14579 A1, 2013 ;
Location in patent: Page/Page column 14; 15 ;
反应条件
potassium fluoride; lt;(dcpe)PdCl2gt; in N,N-dimethyl-formamide
T=120°C; 48 h;
参考文献
Gouda, Ken-Ichi; Hagiwara, Emiko; Hatanaka, Yasuo; Hiyama, Tamejiro
Journal of Organic Chemistry, 1996 , vol. 61, # 21 p. 7232 - 7233
反应条件
cesium fluoride; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether
T=75°C; Suzuki-Kumada coupling; 3 h;
参考文献
Thiemann, Thies; Umeno, Kuniharu; Wang, Jian; Tabuchi, Yumiko; Arima, Kazuya; Watanabe, Masataka; Tanaka, Yasuko; Gorohmaru, Hideki; Mataka, Shuntaro
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 18 p. 2090 - 2110
反应条件
1: 1-chloro-1-(4'-methoxyphenyl)silacyclobutane With tetrabutyl ammonium fluoride in tetrahydrofuran
2: 4'-iodoacetophenone With tri-tert-butyl phosphine; tetrabutyl ammonium fluoride; bis(η3-allyl-μ-chloropalladium(II)) in tetrahydrofuran
1 h; Heating; Further stages.;
参考文献
Denmark, Scott E.; Wu, Zhicai
Organic Letters, 1999 , vol. 1, # 9 p. 1495 - 1498
反应条件
tetrakis(triphenylphosphine) palladium(0)
T=80°C; Stille cross-coupling; 17 h; Ionic liquidInert atmosphere;
参考文献
Hao, Wenyan; Xi, Zhiwen; Cai, Mingzhong
Synthetic Communications, 2012 , vol. 42, # 16 p. 2396 - 2406
反应条件
anhydrous dipotassium phosphate; [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane
T=100 - 110°C; Suzuki-Miyaura coupling reaction; Inert atmosphere;
参考文献
Gao, Han; Li, You; Zhou, Yi-Guo; Han, Fu-She; Lin, Ying-Jie
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 2-3 p. 309 - 314
反应条件
1.1: BuLi / diethyl ether; hexane / 1 h / -78 °C
1.2: 63 percent / diethyl ether; hexane / 13 h / 20 °C
2.1: 50 percent / Ag2O / Pd(PPh3)4 / tetrahydrofuran / 36 h / 60 °C
View Scheme
参考文献
Hirabayashi, Kazunori; Kawashima, Jun; Nishihara, Yasushi; Mori, Atsunori; Hiyama, Tamejiro
Organic Letters, 1999 , vol. 1, # 2 p. 299 - 301
反应条件
morpholine; C31H45Cl2N3OPd; caesium carbonate in water
T=110°C; Suzuki-Miyaura Coupling; 12 h; Inert atmosphere;
参考文献
Wang, Zhan-Yong; Ma, Qin-Na; Li, Ren-Hao; Shao, Li-Xiong
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 45 p. 7899 - 7906
反应条件
catalyst 1 (aliphatic, phosphine based pincer complex of palladium) in 1,4-dioxane; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; 0.5 h;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 48 p. 12939 - 12941
