1-(4-甲氧基-联苯-4-基)-乙酮合成路线 （共 91 条）
反应条件
[Ni0(1,5-cyclooctadiene)2]; potassium phosphate in tetrahydrofuran
T=20°C; 10 h;
参考文献
Xing, Chun-Hui; Hu, Qiao-Sheng
Tetrahedron Letters, 2010 , vol. 51, # 6 p. 924 - 927
反应条件
1: 4-MeOC6H4MgX, X = halide With zinc(II) chloride in tetrahydrofuran
T=25°C; 0.25 h; Inert atmosphere;
2: para-bromoacetophenone With [(C10H13-1,3-(CH2P(Cy)2)2)Pd(Cl)] in tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; Inert atmosphereResealed tube;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 35 p. 8996 - 9003
反应条件
1: 1-bromo-4-methoxy-benzene With Zn(OPiv)2*2LiCl; magnesium in tetrahydrofuran
T=22°C; 2 h; Inert atmosphere;
2: para-chloroacetophenone With PEPPSITM-IPr in tetrahydrofuran
T=25°C; Negishi coupling reaction; 2 h; Inert atmosphere;
参考文献
Bernhardt, Sebastian; Manolikakes, Georg; Kunz, Thomas; Knochel, Paul
Angewandte Chemie - International Edition, 2011 , vol. 50, # 39 p. 9205 - 9209
反应条件
1: potassium carbonate / acetone / 20 °C
2: palladium diacetate; morpholine; potassium phosphate / isopropyl alcohol / 2 h / 80 °C / |Inert atmosphere
View Scheme
参考文献
Abe, Taichi; Mino, Takashi; Watanabe, Kohei; Yagishita, Fumitoshi; Sakamoto, Masami
European Journal of Organic Chemistry, 2014 , vol. 2014, # 18 p. 3909 - 3916
反应条件
in sulfuric acid; water; acetic acid
1.) 16 h, rt. 2.) 7 h, reflux.;
参考文献
Dasgupta, Ratna; Kanjilal, Pranab R.; Patra, Swapan K.; Sarkar, Manish; Ghatak, Usha Ranjan
Tetrahedron, 1985 , vol. 41, # 23 p. 5619 - 5626
反应条件
N,N,N',N,-tetramethylethylenediamine
T=20°C; 16 h; UV-irradiation; Overall yield = 94 percent; Overall yield = 43 mg;
参考文献
Zheng, Xingliang; Yang, Luo; Du, Weiyuan; Ding, Aishun; Guo, Hao
Chemistry - An Asian Journal, 2014 , vol. 9, # 2 p. 439 - 442
反应条件
1: hydrogenchloride / water
2: triphenyl phosphite; K3PO4*3H2O; palladium diacetate; Ipr.HCl / tert-butyl alcohol / 6 h / 80 °C / |Inert atmosphere
View Scheme
参考文献
Chen, Xiaofeng; Ke, Haihua; Chen, Yao; Guan, Changwei; Zou, Gang
Journal of Organic Chemistry, 2012 , vol. 77, # 17 p. 7572 - 7578
反应条件
aluminium trichloride in chlorobenzene
参考文献
Dovgosheya,M.I.; Mil'ner,R.S.
J. Gen. Chem. USSR (Engl. Transl.), 1964 , vol. 34, # 3 p. 977 - 980,969 - 971
反应条件
1: 1.) NaOMe, MeOH. 2.) (COCl)2, Py-C6H6.
2: diethyl ether / 2 h / -5 - 0 °C
3: 51 percent / acetic acid; H2SO4; H2O / 1.) 16 h, rt. 2.) 7 h, reflux.
View Scheme
参考文献
Dasgupta, Ratna; Kanjilal, Pranab R.; Patra, Swapan K.; Sarkar, Manish; Ghatak, Usha Ranjan
Tetrahedron, 1985 , vol. 41, # 23 p. 5619 - 5626
反应条件
1: diethyl ether / 2 h / -5 - 0 °C
2: 51 percent / acetic acid; H2SO4; H2O / 1.) 16 h, rt. 2.) 7 h, reflux.
View Scheme
参考文献
Dasgupta, Ratna; Kanjilal, Pranab R.; Patra, Swapan K.; Sarkar, Manish; Ghatak, Usha Ranjan
Tetrahedron, 1985 , vol. 41, # 23 p. 5619 - 5626
