7-[(1R,2R,3R,5S)-3,5-二羟基-2-[(1E,3R)-3-羟基-5-苯基-1-戊烯-1-基]环戊基]-(5Z)-5-庚烯酸 1-甲基乙基酯合成路线 （共 4 条）
反应条件
sodium tetrahydroborate; cerium(III) chloride in methanol; dichloromethane 0.5 h;
参考文献
Liljebris, Charlotta; Nilsson, Bjoern M.; Resul, Bahram; Hacksell, Uli
Journal of Organic Chemistry, 1996 , vol. 61, # 12 p. 4028 - 4034
反应条件
1: 80 percent / DBU / acetone / 10 h / Ambient temperature 2: 76 percent / DDQ / dioxane / 24 h / Ambient temperature 3: 41 percent / NaBH4, CeCl3*7H2O / CH2Cl2; methanol / 0.5 h View Scheme
参考文献
Resul, Bahram; Stjernschantz, Johan; No, Kiyo; Liljebris, Charlotta; Selen, Goeran; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 2 p. 243 - 248
反应条件
1: 76 percent / DDQ / dioxane / 24 h / Ambient temperature 2: 41 percent / NaBH4, CeCl3*7H2O / CH2Cl2; methanol / 0.5 h View Scheme
参考文献
Resul, Bahram; Stjernschantz, Johan; No, Kiyo; Liljebris, Charlotta; Selen, Goeran; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 2 p. 243 - 248
反应条件
1: 1.) PhB(OH)2, molecular sieves 3A, 2.) PCC, AlCl3, 3.) DIPEA, LiCl, 4.) aq. H2O2 2: 1.) CeCl3*7H2O, 2.) NaBH4 / 1.) MeOH, CH2Cl2, -78 deg C, 30 min, 2.) -78 deg C, 1 h View Scheme
参考文献
Liljebris, Charlotta; Nilsson, Bjoern M.; Resul, Bahram; Hacksell, Uli
Journal of Organic Chemistry, 1996 , vol. 61, # 12 p. 4028 - 4034
