4-氨基-1-[(2R,3E,4S,5R)-3-(氟亚甲基)-4-羟基-5-(羟基甲基)四氢呋喃-2-基]嘧啶-2-酮合成路线 （共 5 条）
反应条件
potassium fluoride in methanol; water T=42 - 55°C;
参考文献
CHIRON CORPORATION
Patent: WO2005/49563 A2, 2005 ;
Location in patent: Page/Page column 2; 5; 9-10 ;
反应条件
cesium fluoride in methanol
参考文献
McCarthy; Matthews; Stemerick; Huber; Bey; Lippert; Snyder; Sunkara
Journal of the American Chemical Society, 1991 , vol. 113, # 19 p. 7439 - 7440
反应条件
ammonia; cesium fluoride in methanol
参考文献
McCarthy; Matthews; Stemerick; Huber; Bey; Lippert; Snyder; Sunkara
Journal of the American Chemical Society, 1991 , vol. 113, # 19 p. 7439 - 7440
反应条件
1: 81 percent / LiHMDS, ClP(O)(OEt)2 2: 1.) Bu3SnH, AlBN, 2.) NH3 / 1.) benzene, 2.) methanol 3: 60 percent / CsF / methanol View Scheme
参考文献
McCarthy; Matthews; Stemerick; Huber; Bey; Lippert; Snyder; Sunkara
Journal of the American Chemical Society, 1991 , vol. 113, # 19 p. 7439 - 7440
反应条件
1: 1.) Bu3SnH, AlBN, 2.) NH3 / 1.) benzene, 2.) methanol 2: 60 percent / CsF / methanol View Scheme
参考文献
McCarthy; Matthews; Stemerick; Huber; Bey; Lippert; Snyder; Sunkara
Journal of the American Chemical Society, 1991 , vol. 113, # 19 p. 7439 - 7440
