4-(BOC-氨基)环己甲酸合成路线 （共 4 条）
反应条件
1: With sodium hydroxide in water; tert-butyl alcohol T=0 - 20°C; 2: With hydrogenchloride in hexane; water pH=~ 6;
参考文献
GLAXO GROUP LIMITED; JONES, Graham, Elgin; MARKWELL, Roger, Edward; HENNESSY, Alan Joseph; MILES, Timothy; PEARSON, Neil David
Patent: WO2010/45987 A1, 2010 ;
Location in patent: Page/Page column 43-44 ;
反应条件
1: 16 percent / H2 / PtO2 / ethanol; H2O / 20 °C / 2689.17 Torr 2: 66 percent / aq. NaOH / 2-methyl-propan-2-ol View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 36, # 3 p. 265 - 286
反应条件
in di-isopropyl ether; ethyl acetate Product distribution / selectivity;
参考文献
TANABE SEIYAKU CO., LTD.
Patent: EP1640373 A1, 2006 ;
Location in patent: Page/Page column 24 ;
参考文献
Tanabe Seiyaku Co., Ltd.
Patent: EP1323710 A1, 2003 ;
