4-氨基丁酸甲酯 盐酸盐合成路线 （共 17 条）
反应条件
4Å molecular sieves in dichloromethane T=20°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2006/76246 A2, 2006 ;
Location in patent: Page/Page column 78 ;
WO 2006/076246 A2
反应条件
potassium hydroxide; potassium carbonate
T=-5 - 20°C; 2 h;
参考文献
Maibaum, Juergen; Stutz, Stefan; Goeschke, Richard; Rigollier, Pascal; Yamaguchi, Yasuchika; Cumin, Frederic; Rahuel, Joseph; Baum, Hans-Peter; Cohen, Nissim-Claude; Schnell, Christian R.; Fuhrer, Walter; Gruetter, Markus G.; Schilling, Walter; Wood, Jeanette M.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 20 p. 4832 - 4844
反应条件
1: 67 percent / Et3N; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / CH2Cl2 / 0 - 20 °C
2: 85 percent / NaBr; 4-acetamido-2,2,6,6-tetramethylpiperidine-1-yloxy; aq. NaOCl / NaHCO3 / toluene; ethyl acetate / 1.25 h / -5 - 0 °C
View Scheme
参考文献
Kokotos, George; Six, David A.; Loukas, Vassilios; Smith, Timothy; Constantinou-Kokotou, Violetta; Hadjipavlou-Litina, Dimitra; Kotsovolou, Stavroula; Chiou, Antonia; Beltzner, Christopher C.; Dennis, Edward A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3615 - 3628
反应条件
(i) NaBH3CN, NaOAc, Na2SO4, MeOH, Et2O, (ii) aq. KOH, EtOH, tBuOH; Multistep reaction;
参考文献
Boots; Guyer; Marecki
Journal of Pharmaceutical Sciences, 1976 , vol. 65, # 9 p. 1374 - 1380
反应条件
1: With triethylamine in dichloromethane
2: With methyl chloroformate in dichloromethane
4 h; Reflux;
参考文献
Mueller, Mathias Q.; Dreiocker, Frank; Ihling, Christian H.; Schaefer, Mathias; Sinz, Andrea
Journal of Mass Spectrometry, 2010 , vol. 45, # 8 p. 880 - 891
反应条件
thiophosgene; chloroform; sodium carbonate
参考文献
Kjaer; Gmelin
Acta Chemica Scandinavica (1947-1973), 1957 , vol. 11, p. 577
反应条件
1: 6 h / Reflux
2: diisopropylamine; trichlorophosphate / dichloromethane / 2 h / 0 - 20 °C / Cooling with ice
View Scheme
参考文献
Kreye, Oliver; Tueruenc, Oguz; Sehlinger, Ansgar; Rackwitz, Jenny; Meier, Michael A. R.
Chemistry - A European Journal, 2012 , vol. 18, # 18 p. 5767 - 5776
