反应条件
1: TFA / 1.) CH2Cl2, from -10 deg C to 0 deg C, 4 h,2.) THF, water, RT, 18 h 2: 68 percent / HOBT, N-methylmorpholine, EDC / dimethylformamide / 24 h / Ambient temperature View Scheme
参考文献
Boyd; Fung; Baker; Mantei; Armiger; Stein; Cohen; Egan; Barlow; Klinghofer; Verburg; Martin; Young; Polakowski; Hoffman; Garren; Perun; Kleinert
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1735 - 1746
