3,5-二氯-2,2,2-三氟苯乙酮合成路线 （共 9 条）
反应条件
1: 1-bromo-3,5-dichloro-benzene With diisobutylaluminium hydride; magnesium in tetrahydrofuran; hexane Reflux; 2: 2,2,2-trifluoro-N-methoxy-N-methylacetamide in tetrahydrofuran; hexane T=0°C; 3: With water; ammonium chloride in tetrahydrofuran; hexane
参考文献
BASF SE; Rack, Michael; Koerber, Karsten
Patent: WO2010/125130 A1, 2010 ;
Location in patent: Page/Page column 41 ;
反应条件
1: 1-bromo-3,5-dichloro-benzene With diisobutylaluminium hydride; magnesium in tetrahydrofuran; hexane Reflux; 2: trifluoroacetic acid chloride in tetrahydrofuran; hexane T=0°C; 3: With water; ammonium chloride in tetrahydrofuran; hexane
参考文献
BASF SE; Rack, Michael; Koerber, Karsten
Patent: WO2010/125130 A1, 2010 ;
Location in patent: Page/Page column 41 ;
反应条件
1: 1-bromo-3,5-dichloro-benzene With diisobutylaluminium hydride; magnesium in tetrahydrofuran; hexane Reflux; 2: trifluoroacetyl fluoride in tetrahydrofuran; hexane T=0°C; 3: With water; ammonium chloride in tetrahydrofuran; hexane
参考文献
BASF SE; Rack, Michael; Koerber, Karsten
Patent: WO2010/125130 A1, 2010 ;
Location in patent: Page/Page column 41 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 2 h;
参考文献
Nissan Chemical Industries, Ltd.
Patent: EP2172462 A1, 2010 ;
Location in patent: Page/Page column 73; 86 ;
反应条件
1: 1-bromo-3,5-dichloro-benzene With diisobutylaluminium hydride; magnesium in tetrahydrofuran; hexane Reflux; 2: ethyl-α,α,α-trifluoroacetate in tetrahydrofuran; hexane T=0°C; 3: With water; ammonium chloride in tetrahydrofuran; hexane
参考文献
BASF SE; Rack, Michael; Koerber, Karsten
Patent: WO2010/125130 A1, 2010 ;
Location in patent: Page/Page column 41 ;
反应条件
1: 1-bromo-3,5-dichloro-benzene With magnesium Metallation; 2: trifluoroacetic anhydride T=-78°C; Grignard reaction;
参考文献
Fujio, Mizue; Morimoto, Hiroshi; Kim, Hyun-Joong; Tsuno, Yuho
Bulletin of the Chemical Society of Japan, 1997 , vol. 70, # 12 p. 3081 - 3090
反应条件
potassium tert-butylate in tetrahydrofuran
T=20 - 25°C; 1.5 h;
参考文献
BASF SE; Rack, Michael; Koerber, Karsten
Patent: WO2010/125130 A1, 2010 ;
Location in patent: Page/Page column 46 ;
反应条件
potassium tert-butylate in tetrahydrofuran
T=20 - 25°C; 1.5 h; Product distribution / selectivity;
参考文献
BASF SE; KOeRBER, Karsten; KORDES, Markus; RACK, Michael; VON DEYN, Wolfgang; KAISER, Florian
Patent: WO2012/59441 A2, 2012 ;
Location in patent: Page/Page column 51 ;
反应条件
potassium methanolate in tetrahydrofuran
T=18 - 50°C; 5.25 h;
参考文献
BASF SE; Rack, Michael; Koerber, Karsten
Patent: WO2010/125130 A1, 2010 ;
Location in patent: Page/Page column 43 ;
