β-D-呋喃核糖-1,2,3,5-四乙酸酯合成路线 （共 86 条）
反应条件
1: 1.) BSA, 2.) SnCl4 / 1.) DCE, 80 deg C, 2.) room temperature, 30 min, 3.) DCE, 1 day 2: 78 percent / NH3/MeOH / 24 h / Ambient temperature View Scheme
参考文献
Wright, George E.; Dudycz, Lech W.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 175 - 181
反应条件
N,O-bis-(trimethylsilyl)-acetamide; tin(IV) chloride in acetonitrile T=60°C; Vorbruggen nucleosidation reaction; 3 h; Inert atmosphere;
参考文献
Ellermann, Manuel; Paulini, Ralph; Jakob-Roetne, Roland; Lerner, Christian; Borroni, Edilio; Roth, Doris; Ehler, Andreas; Schweizer, W. Bernd; Schlatter, Daniel; Rudolph, Markus G.; Diederich, Francois
Chemistry - A European Journal, 2011 , vol. 17, # 23 p. 6369 - 6381
反应条件
1: With tin(IV) chloride in dichloromethane T=0 - 5°C; 6 h; Inert atmosphere; 2: With water; sodium hydrogencarbonate in dichloromethane T=10°C; 0.5 h; Product distribution / selectivity;
参考文献
PHARMION LLC; RAJENDIRAN, Chinnapillai; NAGARAJAN, Periyandi; VENKATESWARLAU, Jasti
Patent: WO2012/135405 A1, 2012 ;
Location in patent: Page/Page column 64-67 ;
反应条件
trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane; 3-keto-2H,3H-1,2-benzisothiazole 1,1-dioxide in acetonitrile Vorbrueggen Nucleoside Synthesis; Microwave irradiation;
参考文献
Parmenopoulou, Vanessa; Chatzileontiadou, Demetra S.M.; Manta, Stella; Bougiatioti, Stamatina; Maragozidis, Panagiotis; Gkaragkouni, Dimitra-Niki; Kaffesaki, Eleni; Kantsadi, Anastassia L.; Skamnaki, Vassiliki T.; Zographos, Spyridon E.; Zounpoulakis, Panagiotis; Balatsos, Nikolaos A.A.; Komiotis, Dimitris; Leonidas, Demetres D.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 24 p. 7184 - 7193
反应条件
1: With trimethylsilyl trifluoromethanesulfonate in acetonitrile T=20°C; 1.5 h; 2: With methanol T=20°C; 1 h;
参考文献
Dowden, James; Moreau, Christelle; Brown, Richard S.; Berridge, Georgina; Galione, Antony; Potter, Barry V. L.
Angewandte Chemie - International Edition, 2004 , vol. 43, # 35 p. 4637 - 4640
反应条件
trimethylsilyl trifluoromethanesulfonate in 1,2-dichloro-ethane 1.5 h; Heating; Yield given. Yields of byproduct given;
参考文献
Garner, Philip; Ramakanth, Sarabu
Journal of Organic Chemistry, 1988 , vol. 53, # 6 p. 1294 - 1298
反应条件
toluene-4-sulfonic acid in chlorobenzene 12 h; Heating;
参考文献
Boryski; Manikowski
Nucleosides and Nucleotides, 1995 , vol. 14, # 3-5 p. 287 - 290
反应条件
toluene-4-sulfonic acid in chlorobenzene 12 h; Heating;
参考文献
Boryski; Manikowski
Nucleosides and Nucleotides, 1995 , vol. 14, # 3-5 p. 287 - 290
反应条件
1: 1,1,1,3,3,3-hexamethyl-disilazane; trimethylsilyl trifluoromethanesulfonate; 3-keto-2H,3H-1,2-benzisothiazole 1,1-dioxide / acetonitrile / |Microwave irradiation 2: ammonia / methanol / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 24 p. 7184 - 7193
反应条件
1: N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 20 h / 60 °C / Inert atmosphere 2: methylamine View Scheme
参考文献
Ellermann, Manuel; Paulini, Ralph; Jakob-Roetne, Roland; Lerner, Christian; Borroni, Edilio; Roth, Doris; Ehler, Andreas; Schweizer, W. Bernd; Schlatter, Daniel; Rudolph, Markus G.; Diederich, Francois
Chemistry - A European Journal, 2011 , vol. 17, # 23 p. 6369 - 6381
