5-羟基间苯二甲酸二甲酯合成路线 （共 49 条）
反应条件
1: 95 percent / K2CO3 / acetone / Heating
2: 83 percent / 85 percent KOH / methanol; tetrahydrofuran / 6 h / Heating
3: 90 percent / BH3*(CH3)2S / tetrahydrofuran / 0 - 60 °C
4: 91 percent / MnO2 / ethyl acetate / 5 h / Heating
View Scheme
参考文献
Zhao; Thurkauf
Synthetic Communications, 2001 , vol. 31, # 12 p. 1921 - 1926
反应条件
18-crown-6 ether; potassium carbonate in acetone
24 h; Heating;
参考文献
Krishna Maiti, Amiya; Martinez, Ricardo; Mestres, Ramon; Tortajada, Amparo; Villar, Felix
Tetrahedron, 2001 , vol. 57, # 16 p. 3397 - 3401
反应条件
1: 95 percent / K2CO3 / acetone / Heating
2: 81 percent / 85 percent KOH / tetrahydrofuran / Heating
3: 90 percent / BH3*(CH3)2S / tetrahydrofuran / 0 - 60 °C
View Scheme
参考文献
Zhao; Thurkauf
Synthetic Communications, 2001 , vol. 31, # 12 p. 1921 - 1926
反应条件
potassium carbonate; potassium iodide in acetone
68 h; Reflux;
参考文献
Jensen, Thomas Binderup; Terazzi, Emmanuel; Buchwalder, Kerry-Lee; Guenee, Laure; Nozary, Homayoun; Schenk, Kurt; Heinrich, Benoit; Donnio, Bertrand; Guillon, Daniel; Piguet, Claude
Inorganic Chemistry, 2010 , vol. 49, # 18 p. 8601 - 8619
反应条件
potassium carbonate in dimethyl sulfoxide; acetone
22 h; Reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/50619 A1, 2004 ;
Location in patent: Page 29 ;
WO 2004/050619 A1
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=0 - 25°C; Mitsunobu reaction; Inert atmosphere;
参考文献
Feng, Yu; Liu, Zi-Tong; Liu, Ji; He, Yan-Mei; Zheng, Qi-Yu; Fan, Qing-Hua
Journal of the American Chemical Society, 2009 , vol. 131, p. 7950 - 7951
反应条件
1: 5-hydroxy-isophthalic acid dimethyl ester With potassium carbonate in acetone; acetonitrile
0.5 h; Reflux;
2: benzyl chloride in acetone; acetonitrile
Reflux;
参考文献
Gibson, Harry W.; Wang, Hong; Niu, Zhenbin; Slebodnick, Carla; Zhakharov, Lev N.; Rheingold, Arnold L.
Macromolecules, 2012 , vol. 45, # 3 p. 1270 - 1280
参考文献
Warner-Lambert Company
Patent: US4018825 A1, 1977 ;
参考文献
Mowbray, Charles E.; Burt, Catherine; Corbau, Romuald; Gayton, Simon; Hawes, Michael; Perros, Manos; Tran, Isabelle; Price, David A.; Quinton, Faye J.; Selby, Matthew D.; Stupple, Paul A.; Webster, Rob; Wood, Anthony
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 20 p. 5857 - 5860
