(3-亚甲基环丁基)氨基甲酸叔丁酯合成路线 （共 6 条）
反应条件
1: 3-methylidenecyclobutanecarboxylic acid With sodium azide; tetrabutylammomium bromide; zinc trifluoromethanesulfonate in tetrahydrofuran T=40°C; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=45°C;
参考文献
WO2010/132777 A2, ;
Page/Page column 178-179 ;
反应条件
diphenyl phosphoryl azide; triethylamine Reflux;
参考文献
US2013/79324 A1, ;
Paragraph 0936; 0937 ;
US 20130079324 A1
反应条件
in tetrahydrofuran T=45°C;
参考文献
WO2011/44501 A2, ;
Page/Page column 72-73 ;
反应条件
1.1: potassium hydroxide; water / ethanol / 6 h / Reflux 1.2: pH 3 - 4 2.1: sodium azide / tetrabutylammomium bromide; zinc trifluoromethanesulfonate / tetrahydrofuran / 40 °C 3.1: tetrahydrofuran / 45 °C View Scheme
反应条件
1: sodium azide / tetrabutylammomium bromide; zinc trifluoromethanesulfonate / tetrahydrofuran / 40 °C 2: tetrahydrofuran / 45 °C View Scheme
反应条件
1: ozone / methanol; dichloromethane / -78 °C / |Inert atmosphere 2: L-Selectridereg; / tetrahydrofuran / 2.5 h / -72 - 20 °C View Scheme
参考文献
PFIZER INC.; Cheng, Hengmiao; Johnson, JR., Theodore Otto; Kath, John Charles; Liu, Kevin Kun-Chin; Lunney, Elizabeth Ann; Nagata, Asako; Nair, Sajiv Krishnan; Planken, Simon Paul; Sutton, Scott Channing
Patent: US2013/79324 A1, 2013 ;
US 20130079324 A1
