3-((异丙基氨基)甲基)吡咯烷-1-羧酸叔丁酯合成路线 （共 5 条）
反应条件
1: in 1,2-dichloro-ethane 18 h; 2: With sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane 18 h; 3: With methanol in 1,2-dichloro-ethane
参考文献
GLAXOSMITHKLINE LLC; DOCK, Steven, Thomas; MCSHERRY, Allison, K.; MOORE, Michael, Lee; RIDGERS, Lance, Howard; PARRISH, Cynthia, Ann
Patent: WO2013/28445 A1, 2013 ;
Location in patent: Page/Page column 76 ;
反应条件
1.1: dichloromethane / 12 h / 0 - 20 °C 2.1: palladium 10 on activated carbon; palladium(II) oxide hydrate; acetic acid; hydrogen / methanol / 48 h / 20 °C 3.1: triethylamine / methanol / 0.5 h / 0 °C 3.2: 24 h / 0 - 20 °C 4.1: sodium hydroxide / methanol; water / 3 h / 20 °C 5.1: 1,2-dichloro-ethane / 18 h 5.2: 18 h View Scheme
参考文献
GLAXOSMITHKLINE LLC; DOCK, Steven, Thomas; MCSHERRY, Allison, K.; MOORE, Michael, Lee; RIDGERS, Lance, Howard; PARRISH, Cynthia, Ann
Patent: WO2013/28445 A1, 2013 ;
反应条件
1.1: palladium 10 on activated carbon; palladium(II) oxide hydrate; acetic acid; hydrogen / methanol / 48 h / 20 °C 2.1: triethylamine / methanol / 0.5 h / 0 °C 2.2: 24 h / 0 - 20 °C 3.1: sodium hydroxide / methanol; water / 3 h / 20 °C 4.1: 1,2-dichloro-ethane / 18 h 4.2: 18 h View Scheme
参考文献
GLAXOSMITHKLINE LLC; DOCK, Steven, Thomas; MCSHERRY, Allison, K.; MOORE, Michael, Lee; RIDGERS, Lance, Howard; PARRISH, Cynthia, Ann
Patent: WO2013/28445 A1, 2013 ;
反应条件
1.1: triethylamine / methanol / 0.5 h / 0 °C 1.2: 24 h / 0 - 20 °C 2.1: sodium hydroxide / methanol; water / 3 h / 20 °C 3.1: 1,2-dichloro-ethane / 18 h 3.2: 18 h View Scheme
参考文献
GLAXOSMITHKLINE LLC; DOCK, Steven, Thomas; MCSHERRY, Allison, K.; MOORE, Michael, Lee; RIDGERS, Lance, Howard; PARRISH, Cynthia, Ann
Patent: WO2013/28445 A1, 2013 ;
反应条件
1.1: sodium hydroxide / methanol; water / 3 h / 20 °C 2.1: 1,2-dichloro-ethane / 18 h 2.2: 18 h View Scheme
参考文献
GLAXOSMITHKLINE LLC; DOCK, Steven, Thomas; MCSHERRY, Allison, K.; MOORE, Michael, Lee; RIDGERS, Lance, Howard; PARRISH, Cynthia, Ann
Patent: WO2013/28445 A1, 2013 ;
