3-甲氧基-2-萘甲酸甲酯合成路线 （共 25 条）
反应条件
caesium carbonate 32 h; Heating;
参考文献
Sawyer, J. Scott; Beight, Douglas W.; Smith, Edward C. R.; Snyder, David W.; Chastain, Marcia K.; Tielking, Richard L.; Hartley, Lawrence W.; Carlson, Donald G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 893 - 896
反应条件
1: beta-naphthyl methyl ether With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-78 - 20°C; 2 h; 3: methanol Further stages;
参考文献
Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 24 p. 4701 - 4709
反应条件
potassium carbonate; methyl iodide in DMF (N,N-dimethyl-formamide) T=20°C; 0.25 h;
参考文献
EP1449834 A2, ;
Page 16 ;
EP 1449834 A2
反应条件
potassium carbonate in acetone 12 h; Reflux;
参考文献
Legouin, Beatrice; Gayral, Maud; Uriac, Philippe; Cupif, Jean-Francois; Levoin, Nicolas; Toupet, Loic; Van De Weghe, Pierre
European Journal of Organic Chemistry, 2010 , # 28 p. 5503 - 5508
反应条件
potassium carbonate in N,N-dimethyl-formamide T=50°C; 96 h;
参考文献
Motomura, Takahisa; Nakamura, Hideko; Suginome, Michinori; Murakami, Masahiro; Ito, Yoshihiko
Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 1 p. 142 - 146
反应条件
potassium carbonate in water; N,N-dimethyl-formamide
反应条件
1: beta-naphthyl methyl ether With n-butyllithium; potassium tert-butylate in tetrahydrofuran; hexane T=-75°C; 0.75 h; 2: carbon dioxide in tetrahydrofuran; hexane 3: diazomethane in diethyl ether regioselective reaction;
参考文献
Ruzziconi, Renzo; Spizzichino, Sara; Giurg, Miroslav; Castagnetti, Eva; Schlosser, Manfred
Synthesis, 2010 , # 9 art. no. T20809SS, p. 1531 - 1535
反应条件
potassium carbonate in acetone
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 1 p. 171 - 178
反应条件
1: beta-naphthyl methyl ether With n-butyllithium in tetrahydrofuran; hexane T=0°C; 2: carbon dioxide in tetrahydrofuran; hexane T=25°C; 3: diazomethane in diethyl ether regioselective reaction;
参考文献
Synthesis, , # 9 art. no. T20809SS, p. 1531 - 1535
反应条件
1: sulfuric acid 2: sodium methylate View Scheme
参考文献
Journal of the Chemical Society, , vol. 97, p. 1747
