(2R)-2-乙炔-1-吡咯烷羧酸-1,1-二甲基乙酯合成路线 （共 14 条）
反应条件
1: diazomethyl-trimethyl-silane With lithium diisopropyl amide Metallation; 2: (S)-2-formylpyrrolidine-1-carboxylic acid tert-butyl ester Acetylenation;
参考文献
Pinto, Ivan L.; Boyd, Helen F.; Hickey, Deirdre M.B.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 17 p. 2015 - 2017
反应条件
1.1: tetrahydrofuran / 20 °C 2.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; trichloroisocyanuric acid / dichloromethane / 0 - 20 °C 3.1: triphenylphosphine; zinc / dichloromethane / 0.08 h / 20 °C / Inert atmosphere 3.2: 1 h / 20 °C / Inert atmosphere 4.1: sec.-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere View Scheme
参考文献
Cambeiro, Xacobe C.; Pericas, Miquel A.
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 1 p. 113 - 124
反应条件
1.1: tetrahydrofuran / 20 °C 2.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; trichloroisocyanuric acid / dichloromethane / 0 - 20 °C 3.1: triphenylphosphine; zinc / dichloromethane / 0.08 h / 20 °C / Inert atmosphere 3.2: 1 h / 20 °C / Inert atmosphere 4.1: sec.-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere View Scheme
参考文献
Cambeiro, Xacobe C.; Pericas, Miquel A.
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 1 p. 113 - 124
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 25 °C / Inert atmosphere 2.1: tetrahydrofuran / 20 °C 3.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; trichloroisocyanuric acid / dichloromethane / 0 - 20 °C 4.1: triphenylphosphine; zinc / dichloromethane / 0.08 h / 20 °C / Inert atmosphere 4.2: 1 h / 20 °C / Inert atmosphere 5.1: sec.-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere View Scheme
参考文献
Cambeiro, Xacobe C.; Pericas, Miquel A.
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 1 p. 113 - 124
