2,2-二甲基-3-(硝基氧基)丙酸合成路线 （共 4 条）
反应条件
1: With sodium hydroxide in methanol T=20°C; 6 h; 2: With hydrogenchloride in water pH=3 - 4;
参考文献
WO2011/92065 A1, ;
Page/Page column 66-67 ;
WO 2011/092065 A1
反应条件
1: 93 percent / nitric acid; acetic anhydride / cooling 2: 76 percent / NaOH / methanol / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 19 p. 4995 - 4997
反应条件
thionyl chloride; N,N-dimethyl-formamide in chloroform T=20 - 50°C;
参考文献
NitroMed, Inc.
Patent: US2006/189603 A1, 2006 ;
Location in patent: Page/Page column 40 ;
US 20060189603 A1
反应条件
1: 100 percent / SOCl2; DMF / CHCl3 / 20 - 50 °C 2: 74 percent / sodium acetate / H2O; CH2Cl2 / 1.5 h View Scheme
参考文献
Kartasasmita, Rahmana E.; Laufer, Stefan; Lehmann, Jochen
Archiv der Pharmazie, 2002 , vol. 335, # 8 p. 363 - 366
