tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=140°C; 2 h;

palladium diacetate in acetonitrile 6 h; other enaminones; Product distribution;

1: 1.) trifluoroacetic acid, N-chlorosuccinimide, dimethyl sulphide / 1.) CH2Cl2, -20 deg C, 2.) CH2Cl2, RT, 3 h 2: 1.) NaH, 2.) CuI / 1.) HMPA, RT, 30 min, 2.) HMPA, 120 deg C, 2 h View Scheme

1: 1.) trifluoroacetic acid, N-chlorosuccinimide, dimethyl sulphide / 1.) CH2Cl2, -20 deg C, 2.) CH2Cl2, RT, 3 h 2: 1.) NaH, 2.) CuI / 1.) HMPA, RT, 30 min, 2.) HMPA, 120 deg C, 2 h View Scheme