2,2'-二乙基-1,1'-联苯合成路线 （共 12 条）
反应条件
tripotassium phosphate monohydrate; 4-bromo-benzoic acid ethyl ester; C52H49PRu; bis(dibenzylideneacetone)-palladium(0) in 1,4-dioxane T=100°C; Suzuki-Miyaura Coupling; 4 h; Inert atmosphere;
参考文献
Hoshi, Takashi; Honma, Tomonobu; Mori, Ayako; Konishi, Maki; Sato, Tsutomu; Hagiwara, Hisahiro; Suzuki, Toshio
Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11513 - 11524
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
参考文献
Staab,H.A. et al.
Chemische Berichte, 1972 , vol. 105, p. 2310 - 2319
反应条件
1: KOtBu / tetrahydrofuran 2: H2 / Pd-C / ethyl acetate View Scheme
参考文献
Staab,H.A. et al.
Chemische Berichte, 1972 , vol. 105, p. 2310 - 2319
反应条件
1: (i) Ph3P, THF, (ii) PhLi, Et2O, (iii) /BRN= 1209228/ 2: KOtBu / tetrahydrofuran 3: H2 / Pd-C / ethyl acetate View Scheme
参考文献
Staab,H.A. et al.
Chemische Berichte, 1972 , vol. 105, p. 2310 - 2319
反应条件
1: (i) EtMgBr, Et2O, (ii) /BRN= 1209232/ 2: (i) Mg, MeI, I2, (ii) CuCl2 3: aq. KOH 4: H2 / Pd-C / ethyl acetate View Scheme
参考文献
Staab,H.A. et al.
Chemische Berichte, 1972 , vol. 105, p. 2310 - 2319
反应条件
1: aq. KOH 2: H2 / Pd-C / ethyl acetate View Scheme
参考文献
Staab,H.A. et al.
Chemische Berichte, 1972 , vol. 105, p. 2310 - 2319
反应条件
1: (i) Mg, MeI, I2, (ii) CuCl2 2: aq. KOH 3: H2 / Pd-C / ethyl acetate View Scheme
参考文献
Staab,H.A. et al.
Chemische Berichte, 1972 , vol. 105, p. 2310 - 2319
反应条件
copper T=245 - 255°C;
参考文献
Mascarelli; Longo
Gazzetta Chimica Italiana, 1941 , vol. 71, p. 389,392
反应条件
n-butyllithium; KO-t-BuLi 1.) hexane, pentane, 2 h, 2.) THF, 0 deg C, 40 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Bates, Robert B.; Camou, Fernando A.; Kane, Vinayak V.; Mishra, Prasana K.; Suvannachut, Kessara; White, James J.
Journal of Organic Chemistry, 1989 , vol. 54, # 2 p. 311 - 317
反应条件
1.1: hydrogenchloride; sodium nitrite / water; ethanol / 1 h / 0 °C / |Inert atmosphere 1.2: 0.83 h / |Inert atmosphere; |Reflux 2.1: C52H49PRu; tripotassium phosphate monohydrate; bis(dibenzylideneacetone)-palladium(0); 4-bromo-benzoic acid ethyl ester / 1,4-dioxane / 4 h / 100 °C / |Inert atmosphere View Scheme
参考文献
Hoshi, Takashi; Honma, Tomonobu; Mori, Ayako; Konishi, Maki; Sato, Tsutomu; Hagiwara, Hisahiro; Suzuki, Toshio
Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11513 - 11524
