2-氯-3-氧代戊基乙酸酯合成路线 （共 35 条）
反应条件
T=60 - 72°C; intramolecular condensation; 2 h;
参考文献
Pharmaceutical Chemistry Journal, , vol. 32, # 3 p. 161 - 163
反应条件
1: P2S5 2: aqueous HCl View Scheme
参考文献
Hayano et al.
Yakugaku Kenkyu, 1958 , vol. 30, p. 248,255
Chem.Abstr., 1960 , p. 512
参考文献
Koenig et al.
Acta Chimica Academiae Scientiarum Hungaricae, 1953 , vol. 3, p. 157,160
反应条件
1: 43 percent / AcOH; AcONH4; 3 Angstroem molecular sieves / toluene / 6 h / Heating 2: 82 percent / Na2S; AcOH / ethanol / 2 h / -40 - -10 °C 3: 93 percent / CuBr2; t-BuONO / acetonitrile / 0.5 h / 0 °C 4: 94 percent / Zn; AcOH / 16 h / Heating 5: 81 percent / LiAlH4 / diethyl ether / 3 h / Heating 6: 74 percent / MnO2 / CHCl3 / 5 h / 20 °C View Scheme
参考文献
Hawksley, Daniel; Griffin, David A.; Leeper, Finian J.
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 2 p. 144 - 148
反应条件
sodium iodide in water; N,N-dimethyl-formamide T=20°C; 6 h;
参考文献
Uray, Georg; Celotto, Claude; Ibovnik, Anton; Zoltewicz, John A.
Journal of Organic Chemistry, 1989 , vol. 54, # 16 p. 3941 - 3945
反应条件
methanol; ammonia Erwaermen des Reaktionsprodukts mit wss. HCl;
参考文献
Yoshida; Unoki
Yakugaku Zasshi, 1953 , vol. 73, p. 631,634
Chem.Abstr., 1954 , p. 5866
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Matsukawa; Iwatsu
Yakugaku Zasshi, 1950 , vol. 70, p. 28,31
Chem.Abstr., 1950 , p. 4475
反应条件
(i) aq. NaOH, (ii) /BRN= 971207/, /BRN= 1098293/, aq. NH3, EtOH, (iii) aq. HCl, (iV) aq. NaOH; Multistep reaction;
参考文献
Tursin,V.M. et al.
J. Appl. Chem. USSR (Engl. Transl.), 1961 , vol. 34, p. 229 - 232,219 - 221
反应条件
1: 73.5 percent / KSH / methanol / 1 h / Ambient temperature 2: 1.) HCOOH, 2.) HCl / 1.) 30 min, RT, 2.) EtOH, 30 min, RT View Scheme
参考文献
Contant; Forzy; Hengartner; Moine
Helvetica Chimica Acta, 1990 , vol. 73, # 5 p. 1300 - 1305
参考文献
Bergel; Todd
Journal of the Chemical Society, 1938 , p. 26
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Andersag; Westphal
Chemische Berichte, 1937 , vol. 70, p. 2035,2044
Full Text Show Details
Todd; Bergel
Journal of the Chemical Society, 1937 , p. 367
Journal of the Chemical Society, 1938 , p. 28
反应条件
1: 43 percent / AcOH; AcONH4; 3 Angstroem molecular sieves / toluene / 6 h / Heating
2: 82 percent / Na2S; AcOH / ethanol / 2 h / -40 - -10 °C
3: 93 percent / CuBr2; t-BuONO / acetonitrile / 0.5 h / 0 °C
4: 94 percent / Zn; AcOH / 16 h / Heating
View Scheme
参考文献
Hawksley, Daniel; Griffin, David A.; Leeper, Finian J.
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 2 p. 144 - 148
