hydrogen bromide; sodium bromide; sodium nitrite in water T=-5 - 5°C; 4 h;

phosphorus tribromide Bromination;

1: 70 percent / phosphorus oxychloride 2: 80 percent / phosphorus tribromide View Scheme

n-butyllithium; Zinc chloride; tetrakis (triphenylphosphine) palladium (0) in tetrahydrofuran; diethyl ether; hexane

1: 2,6-Dibromopyridine With n-butyllithium in tetrahydrofuran Dehalogenation; 2: With zinc(II) chloride in diethyl ether T=20°C; Metallation; 3: 2-bromo-4-methyl-pyrimidine With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; diethyl ether Substitution; 2 h; Heating;