N1-(4-氯苯基)苯-1,4-二胺合成路线 （共 18 条）
反应条件
iron; ammonium chloride in ethanol; water
T=50°C; 3 h;
参考文献
NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; STOCKING, Emily, M.
Patent: WO2014/26039 A2, 2014 ;
Location in patent: Paragraph 0200 ;
反应条件
perchloric acid; lithium perchlorate in 1,4-dioxane; water
T=0°C; different time; Product distributionMechanism;
参考文献
Rhee, Eun Sook; Shine, Henry J.
Journal of the American Chemical Society, 1986 , vol. 108, # 5 p. 1000 - 1006
反应条件
sodium dithionite
Ambient temperature;
参考文献
Balboni, Claudio; Benati, Luisa; Montevecchi, P. Carlo; Spagnolo, Piero
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 2111 - 2117
反应条件
1: 65 percent / lead dioxide / benzene / Ambient temperature
2: 35 percent / 20percent aq. sodium dithionite / Ambient temperature
View Scheme
参考文献
Balboni, Claudio; Benati, Luisa; Montevecchi, P. Carlo; Spagnolo, Piero
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 2111 - 2117
反应条件
2: 65 percent / lead dioxide / benzene / Ambient temperature
3: 35 percent / 20percent aq. sodium dithionite / Ambient temperature
View Scheme
参考文献
Balboni, Claudio; Benati, Luisa; Montevecchi, P. Carlo; Spagnolo, Piero
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 2111 - 2117
反应条件
1: potassium phosphate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 80 - 100 °C / |Inert atmosphere
2: iron; ammonium chloride / water; ethanol / 3 h / 50 °C
View Scheme
参考文献
NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; STOCKING, Emily, M.
Patent: WO2014/26039 A2, 2014 ;
反应条件
1: potassium phosphate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 80 - 100 °C / |Inert atmosphere
2: iron; ammonium chloride / water; ethanol / 3 h / 50 °C
View Scheme
参考文献
NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; STOCKING, Emily, M.
Patent: WO2014/26039 A2, 2014 ;
反应条件
ammonium chloride; zinc
参考文献
Bamberger; Ham
Justus Liebigs Annalen der Chemie, 1911 , vol. 382, p. 114
反应条件
hydrogenchloride; methanol
参考文献
Jacobson
Justus Liebigs Annalen der Chemie, 1909 , vol. 367, p. 315;
Chem. Zentralbl., 1898 , vol. 69, # II p. 36
反应条件
hydrogenchloride; tin(ll) chloride
参考文献
Jacobson; Struebe
Justus Liebigs Annalen der Chemie, 1898 , vol. 303, p. 310
