(1-吡啶-4-哌啶)-甲醇合成路线 (共 8 条)
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 4 h; Cooling with ice; 2: With water; sodium hydroxide in tetrahydrofuran T=20°C; Cooling with ice;
参考文献
Ajinomoto Co., Inc.
Patent: EP2311810 A1, 2011 ;
Location in patent: Page/Page column 21 ;
反应条件
sodium hydroxide in tetrahydrofuran; water; ethyl acetate
参考文献
Eli Lilly and Company
Patent: US6313122 B1, 2001 ;
US 6313122 B1
反应条件
borane in tetrahydrofuran T=20°C; 12 h;
参考文献
Ajinomoto Co., Inc.
Patent: EP2311810 A1, 2011 ;
反应条件
sodium hydroxide in tetrahydrofuran; water; ethyl acetate
参考文献
Eli Lilly and Company
Patent: US6610704 B1, 2003 ;
US 6610704 B1
反应条件
sodium hydroxide in tetrahydrofuran; water; ethyl acetate
参考文献
Eli Lilly and Company
Patent: US6635657 B1, 2003 ;
US 6635657 B1
反应条件
in tetrahydrofuran; hydrogenchloride
参考文献
Japan Tobacco Inc.
Patent: US6562828 B1, 2003 ;
US 6562828 B1
反应条件
1: Et3N / ethanol / 48 h / 120 °C 2: LiAlH4 / tetrahydrofuran View Scheme
参考文献
Franciskovich, Jeffry B.; Masters, John J.; Tinsley, Jennifer M.; Craft, Trelia J.; Froelich, Larry L.; Gifford-Moore, Donetta S.; Klimkowski, Valentine J.; Smallwood, Jeffrey K.; Smith, Gerald F.; Smith, Tommy; Towner, Richard R.; Weir, Leonard C.; Wiley, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 21 p. 4838 - 4841
反应条件
1: Et3N / ethanol / 48 h / 120 °C 2: LiAlH4 / tetrahydrofuran View Scheme
参考文献
Franciskovich, Jeffry B.; Masters, John J.; Tinsley, Jennifer M.; Craft, Trelia J.; Froelich, Larry L.; Gifford-Moore, Donetta S.; Klimkowski, Valentine J.; Smallwood, Jeffrey K.; Smith, Gerald F.; Smith, Tommy; Towner, Richard R.; Weir, Leonard C.; Wiley, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 21 p. 4838 - 4841