3,4-亚甲基二氧基乙酰苯胺合成路线 （共 16 条）
反应条件
copper; potassium carbonate T=190 - 200°C; 12 h; Yield given;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 24 p. 3439 - 3450
反应条件
iodine cloride; acetic acid in dichloromethane T=20°C; 16 h;
参考文献
UCB PHARMA S.A.
Patent: WO2008/47109 A1, 2008 ;
Location in patent: Page/Page column 55-56 ;
WO 2008/047109 A1
反应条件
1: iodine cloride; acetic acid / dichloromethane / 20 °C 2: sodium hydroxide; water / ethanol / Reflux View Scheme
参考文献
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; SUN, Weilin; TALDONE, Tony; PATEL, Pallav; CHIOSIS, Gabriela
Patent: WO2012/138894 A1, 2012 ;
反应条件
trichlorophosphate Vilsmeier reaction; 2 h; Heating;
参考文献
Elban, Mark A.; Sun, Wenyue; Eisenhauer, Brian M.; Gao, Rong; Hecht, Sidney M.
Organic Letters, 2006 , vol. 8, # 16 p. 3513 - 3516
反应条件
nitric acid in water; acetic acid
T=15 - 20°C; 16 h;
参考文献
Hay, Michael P.; Hicks, Kevin O.; Pchalek, Karin; Lee, Ho H.; Blaser, Adrian; Pruijn, Frederik B.; Anderson, Robert F.; Shinde, Sujata S.; Wilson, William R.; Denny, William A.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 21 p. 6853 - 6865
反应条件
sodium acetate; palladium diacetate; p-benozquinone in 1,4-dioxane
T=20 - 60°C; P=760.051 Torr;
参考文献
Giri, Ramesh; Lam, Jonathan K.; Yu, Jin-Quan
Journal of the American Chemical Society, 2010 , vol. 132, # 2 p. 686 - 693
