反应条件
1.1: sodium hydride / mineral oil / 0.75 h / 20 °C 1.2: 20 °C 2.1: tri-n-butyl-tin hydride / 2,2'-azo-bisisobutyronitrile / benzene / 0.33 h / Reflux 3.1: sodium methylate; methanol / 5 h / 20 °C 4.1: triphenylphosphine; diethylazodicarboxylate / benzene / 20 °C 5.1: sodium methylate; methanol / 3 h / 20 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; SRINIVASU, Pothukanuri; BENDER, John A.; LOPEZ, Omar D.; CHEN, Qi; RAMPULLA, Richard A.; GUPTA, Samayamunthula Venkata Satya Arun Kumar; MEANWELL, Nicholas A.
Patent: WO2012/21591 A1, 2012 ;
WO 2012/021591 A1
