(R)-(+)-1-苄基丙三醇合成路线 （共 40 条）
反应条件
pyridine in chloroform T=20°C; Acylation; 48 h;
参考文献
Takahashi, Toshihiro; Ido, Tatsuo; Nagata, Shinji; Iwata, Ren
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 9 p. 943 - 969
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=0°C;
参考文献
Martin, Stephen F.; Josey, John A.
Tetrahedron Letters, 1988 , vol. 29, # 30 p. 3631 - 3634
反应条件
1: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate T=65°C; Alkylation; 5 h; 2: With hydrogenchloride in methanol; dichloromethane T=20°C; deprotection; 2 h;
参考文献
Bhattacharya, Santanu; Dileep
Tetrahedron Letters, 1999 , vol. 40, # 46 p. 8167 - 8171
反应条件
(i) Ph3CCl, Py, (ii) NaH, DMF, (iii) /BRN= 969135/; Multistep reaction;
参考文献
Holy,A.
Collection of Czechoslovak Chemical Communications, 1978 , vol. 43, p. 3444 - 3465
反应条件
1: Pseudomonas cepacia lipase / tetrahydrofuran; hexane
2: triphenylphosphine; diethyl azodicarboxylate / diethyl ether / 24 h
View Scheme
参考文献
Herradon; Cueto; Morcuende; Valverde
Tetrahedron Asymmetry, 1993 , vol. 4, # 5 p. 845 - 864
反应条件
in tetrahydrofuran; hexane
35.5 h; Ambient temperaturePseudomonas fluorescens lipase (PFL); Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Guanti, Giuseppe; Banfi, Luca; Basso, Andrea; Bevilacqua, Elisabetta; Bondanza, Laura; Riva, Renata
Tetrahedron Asymmetry, 2004 , vol. 15, # 18 p. 2889 - 2892
反应条件
in tetrahydrofuran
16 h; Ambient temperaturePseudomonas cepacia lipase (LPA); Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Herradon; Cueto; Morcuende; Valverde
Tetrahedron Asymmetry, 1993 , vol. 4, # 5 p. 845 - 864
反应条件
sodium hydroxide in tetrahydrofuran; water
Heating;
参考文献
Hu, Hui; Bartsch, Richard A.
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 4 p. 557 - 562
反应条件
sodium hydroxide in 1,4-dioxane
24 h; Heating;
参考文献
Ctech, Bronislav
Tetrahedron Letters, 1980 , vol. 21, p. 4197 - 4198
反应条件
1: 1.) Li, t-butanol, 2.) LiBr / 2.) H2O, reflux 15 days
2: 99 percent / conc. HCl / CH2Cl2; methanol / 2 h / Ambient temperature
3: 70 percent / NaOH, p-toluenesulfonyl chloride / dioxane / 24 h / 60 °C
View Scheme
参考文献
Son; Czech; Bartsch
Synthesis, 1984 , vol. NO. 9, p. 776 - 778
