4-氯吡啶-2-羧酸叔丁酯合成路线 （共 14 条）
反应条件
1: 25percent HBr / 2 h / Ambient temperature 2: 44 percent / methanol / 7 h / 140 °C View Scheme
参考文献
Australian Journal of Chemistry, , vol. 35, # 10 p. 2025 - 2034
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; 18 h;
参考文献
SIGA TECHNOLOGIES, INC.; DAI, Dongcheng; BURGESON, James, R.; AMBERG, Sean, M.; HRUBY, Dennis, E.
Patent: WO2013/123215 A2, 2013 ;
Location in patent: Paragraph 0000228 ;
反应条件
1.1: n-butyllithium / hexane / 1.5 h / -78 - -72 °C
1.2: 2 h / -75 - -72 °C
2.1: trifluoroacetic acid / dichloromethane / 21.5 h / 0 - 20 °C
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FADER, Lee; LEPAGE, Olivier; BAILEY, Murray; BEAULIEU, Pierre Louis; BILODEAU, François; CARSON, Rebekah; GIROUX, André; GODBOUT, Cédrickx; MOREAU, Benoît; NAUD, Julie; PARISIEN, Mathieu; POIRIER, Martin; POIRIER, Maude; SURPRENANT, Simon; THIBEAULT, Carl
Patent: WO2013/152063 A1, 2013 ;
反应条件
1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C
2: sodium hydrogencarbonate / ethanol; water / 20 h / 20 °C / |Reflux
3: N-iodo-succinimide / N,N-dimethyl-formamide / 6 h / 20 °C
View Scheme
参考文献
SIGA TECHNOLOGIES, INC.; DAI, Dongcheng; BURGESON, James, R.; AMBERG, Sean, M.; HRUBY, Dennis, E.
Patent: WO2013/123215 A2, 2013 ;
