4-(5-氟-3-羟基苯基)-4-甲氧基-3,4,5,6-四氢-2H-吡喃合成路线 （共 5 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol 2 h;
参考文献
Crawley; Dowell; Edwards; Foster; McMillan; Walker; Waterson
Journal of Medicinal Chemistry, 1992 , vol. 35, # 14 p. 2600 - 2609
反应条件
hydrogenchloride; palladium in tetrahydrofuran; mineral oil; methyl iodide
参考文献
Imperial Chemical Industries PLC; ICI Pharma
Patent: US5254581 A1, 1993 ;
US 5254581 A
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 66 percent / tetrahydrofuran; hexane / -78 - 4 °C 2.1: 67 percent / NaH / dimethylformamide / 3 h / 20 °C 3.1: 94 percent / H2 / Pd(OH)2/C / ethanol / 15 h / 20 °C / atmospheric pressure View Scheme
参考文献
Crawley; Dowell; Edwards; Foster; McMillan; Walker; Waterson
Journal of Medicinal Chemistry, 1992 , vol. 35, # 14 p. 2600 - 2609
反应条件
1.1: NaH / N,N-dimethyl-acetamide / 0.5 h / 4 °C 1.2: 63 percent / N,N-dimethyl-acetamide / 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: 66 percent / tetrahydrofuran; hexane / -78 - 4 °C 3.1: 67 percent / NaH / dimethylformamide / 3 h / 20 °C 4.1: 94 percent / H2 / Pd(OH)2/C / ethanol / 15 h / 20 °C / atmospheric pressure View Scheme
参考文献
Crawley; Dowell; Edwards; Foster; McMillan; Walker; Waterson
Journal of Medicinal Chemistry, 1992 , vol. 35, # 14 p. 2600 - 2609
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 66 percent / tetrahydrofuran; hexane / -78 - 4 °C 2.1: 67 percent / NaH / dimethylformamide / 3 h / 20 °C 3.1: 94 percent / H2 / Pd(OH)2/C / ethanol / 15 h / 20 °C / atmospheric pressure View Scheme
参考文献
Crawley; Dowell; Edwards; Foster; McMillan; Walker; Waterson
Journal of Medicinal Chemistry, 1992 , vol. 35, # 14 p. 2600 - 2609
