(3R,6R)-3,6-二甲基-1,4-二恶烷-2,5-二酮合成路线 （共 30 条）
反应条件
1: T=70°C; P=60.006 Torr;
2: With stannous octanoate
T=70 - 250°C; P=7.50075 - 15.0015 Torr;
参考文献
Futerro S.A.; Coszach, Philippe; Mariage, Pierre-Antoine
Patent: US8592609 B2, 2013 ;
Location in patent: Page/Page column 3; 4; 5 ;
反应条件
in n-heptane; water
T=128°C; 32 h; Heating / reflux; Product distribution / selectivity;
参考文献
Millennium Specialty Chemicals, Inc.
Patent: US7173146 B1, 2007 ;
Location in patent: Page/Page column 5-6 ;
反应条件
1: in water
T=170°C; P=80 Torr; 3 h;
2: With tin catalyst
T=220°C; P=10 - 15 Torr; Product distribution / selectivity;
参考文献
NATUREWORKS LLC; BENSON, Richard, Douglas; SUMNER, Eric, Stanley; SCHROEDER, Joseph, David
Patent: WO2010/105143 A2, 2010 ;
Location in patent: Page/Page column 32-35 ;
反应条件
1: With 3-chloropyridinium triflate
T=140°C; P=25 Torr; 12 h;
2: T=160°C; P=1 Torr; 3 h;
3: With methanol; potassium carbonate
Reagent/catalystPressureTemperatureTime;
参考文献
Ishijima, Yuuki; Maruta, Yasumi; Abiko, Atsushi
Chemistry Letters, 2012 , vol. 41, # 11 p. 1456 - 1458
反应条件
1: With 2,4,6-trichloro-1,3,5-triazine in acetone
T=20°C;
2: With triethylamine in acetone
1 h; Further stages.;
参考文献
Leemhuis, Mark; Van Steenis, Jan Hein; Van Uxem, Michelle J.; Van Nostrum, Cornelus F.; Hennink, Wim E.
European Journal of Organic Chemistry, 2003 , # 17 p. 3344 - 3349
反应条件
1.1: 100 percent / hydrogen / Pd/C / ethanol / 20 °C
2.1: cyanuric chloride / acetone / 20 °C
2.2: Et3N / acetone / 1 h
View Scheme
参考文献
Leemhuis, Mark; Van Steenis, Jan Hein; Van Uxem, Michelle J.; Van Nostrum, Cornelus F.; Hennink, Wim E.
European Journal of Organic Chemistry, 2003 , # 17 p. 3344 - 3349
反应条件
Na-ethylhexanoate
T=160°C; 15 h; RacemisationParr reactor; Product distribution / selectivity;
参考文献
NATUREWORKS LLC; BENSON, Richard, Douglas; SCHROEDER, Joseph, David
Patent: WO2010/105142 A1, 2010 ;
Location in patent: Page/Page column 23; 24 ;
反应条件
Amberlysreg; 36 resin
T=104 - 115°C; P=25 - 80 Torr; 28 h; Heating / reflux;
参考文献
CARGILL, INCORPORATED
Patent: EP1247808 A2, 2002 ;
Location in patent: Page 20 ;
反应条件
N-Me-ephedrine in toluene
T=110°C; 30 h;
参考文献
Shuklov, Ivan A.; Jiao, Haijun; Schulze, Joachim; Tietz, Wolfgang; Kuehlein, Klaus; Boerner, Armin
Tetrahedron Letters, 2011 , vol. 52, # 9 p. 1027 - 1030
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in toluene
T=20°C; 48 h;
参考文献
Shuklov, Ivan A.; Jiao, Haijun; Schulze, Joachim; Tietz, Wolfgang; Kuehlein, Klaus; Boerner, Armin
Tetrahedron Letters, 2011 , vol. 52, # 9 p. 1027 - 1030
