1-(3-氯苯基)哌嗪盐酸盐合成路线 （共 7 条）
参考文献
Farmaco, Edizione Scientifica, , vol. 43, # 12 SUPPL. p. 1053 - 1062
反应条件
hydrogenchloride; sodium hydroxide in water; acetone
参考文献
Mead Johnson and Company
Patent: US4252806 A1, 1981 ;
反应条件
sodium hydroxide in hydrogenchloride; water; acetone
参考文献
Apotex, Inc.
Patent: US5900485 A1, 1999 ;
反应条件
4-(N,N-dimethlyamino)pyridine; 1,2-dichloro-ethane; triethylamine; chloroacetic acid in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran
参考文献
PAJOUHESH, Hassan; PAJOUHESH, Hossein; DING, Yanbing; TAN, Jason; GRIMWOOD, Mike; BELARDETTI, Francesco; KAUL, Ramesh
Patent: US2008/280900 A1, 2008 ;
反应条件
triethylamine in chloroform
T=0°C; 2 h;
参考文献
Oshiro; Sakurai; Tanaka; Kikuchi; Hirose; Tottori
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2014 - 2023
反应条件
sodium hydroxide in dichloromethane; water; dimethyl sulfoxide
参考文献
Helton, David Reed; Fick, David; Pfadenhauer, Ernie; Sharp, Jason
Patent: US2005/107439 A1, 2005 ;
Location in patent: Page/Page column 9 ;
反应条件
in water; N,N-dimethyl-formamide
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4603135 A1, 1986 ;
