1: 98.7 percent / acetic acid / 6 h / 60 °C
2: Na, propanol / 1 h / Heating
3: conc. HCl / propan-2-ol; H2O / 6 h / 20 - 130 °C
4: 1.) LDA / 1.) THF, hexane, -75 deg C, 20 min, 2.) THF, hexane, -75 deg C, 30 min
View Scheme
参考文献
Huegi, Bruno S.; Ebnoether, Anton M.; Rissi, Erwin; Gadient, Fulvio; Hauser, Daniel; et al.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 42 - 50
1: 98.7 percent / acetic acid / 6 h / 60 °C
2: Na, propanol / 1 h / Heating
3: conc. HCl / propan-2-ol; H2O / 6 h / 20 - 130 °C
View Scheme
参考文献
Huegi, Bruno S.; Ebnoether, Anton M.; Rissi, Erwin; Gadient, Fulvio; Hauser, Daniel; et al.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 42 - 50