您好，欢迎来到魔法化学网！
合作交流
|
服务时间(9:30-18:00)
百科
百科
▼
百科
资讯
搜索
结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
首页
化合物百科
价格行情
资讯
化工导航
实验室工具
搜索
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
1307853-51-5
合成路线
（共 6 条）
1307853-51-5
→
反应条件
114798-36-6
氯沙坦甲醛
反应条件
1: With methoxybenzene; trifluoroacetic acid T=20 - 80°C; 13 h; 2: With potassium hydroxide in water; toluene
参考文献
Seki, Masahiko; Nagahama, Masaki
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 10198 - 10206
1307853-51-5
→
反应条件
114798-26-4
洛沙坦
反应条件
1: methoxybenzene; trifluoroacetic acid / 13 h / 20 - 80 °C 2: sodium tetrahydroborate; sodium hydroxide / water / 4.42 h / 5 - 20 °C View Scheme
参考文献
Seki, Masahiko; Nagahama, Masaki
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 10198 - 10206
41882-10-4
→
反应条件
1307853-51-5
反应条件
<b>Multi-step reaction with 5 steps<br /> </b>1.1: phosphorus pentachloride / dichloromethane / 1.18 h / -16 - 17 °C<br />1.2: 8.2 h / -10 - 20 °C<br />2.1: 1-methyl-pyrrolidin-2-one; [Ru(COD)(Cl<sub>2</sub>)]2; triphenylphosphine / 2 h / 140 °C<br />3.1: methanol; sodium methylate / 1.5 h / 20 °C<br />4.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C<br />5.1: potassium carbonate / N,N-dimethyl acetamide / 8 h / -10 - 20 °C<br /> <br />
参考文献
Seki, Masahiko; Nagahama, Masaki Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 10198 - 10206
98-88-4
苯甲酰氯
→
反应条件
1307853-51-5
反应条件
<b>Multi-step reaction with 6 steps<br /> </b>1.1: triethylamine / tetrahydrofuran / 3 h / 16 - 20 °C<br />2.1: phosphorus pentachloride / dichloromethane / 1.18 h / -16 - 17 °C<br />2.2: 8.2 h / -10 - 20 °C<br />3.1: 1-methyl-pyrrolidin-2-one; [Ru(COD)(Cl<sub>2</sub>)]2; triphenylphosphine / 2 h / 140 °C<br />4.1: methanol; sodium methylate / 1.5 h / 20 °C<br />5.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C<br />6.1: potassium carbonate / N,N-dimethyl acetamide / 8 h / -10 - 20 °C<br /> <br />
参考文献
Seki, Masahiko; Nagahama, Masaki Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 10198 - 10206
2393-23-9
4-甲氧基苄胺
→
反应条件
1307853-51-5
反应条件
<b>Multi-step reaction with 6 steps<br /> </b>1.1: triethylamine / tetrahydrofuran / 3 h / 16 - 20 °C<br />2.1: phosphorus pentachloride / dichloromethane / 1.18 h / -16 - 17 °C<br />2.2: 8.2 h / -10 - 20 °C<br />3.1: 1-methyl-pyrrolidin-2-one; [Ru(COD)(Cl<sub>2</sub>)]2; triphenylphosphine / 2 h / 140 °C<br />4.1: methanol; sodium methylate / 1.5 h / 20 °C<br />5.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C<br />6.1: potassium carbonate / N,N-dimethyl acetamide / 8 h / -10 - 20 °C<br /> <br />
参考文献
Seki, Masahiko; Nagahama, Masaki Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 10198 - 10206
824-94-2
4-甲氧基氯苄
→
反应条件
1307853-51-5
反应条件
<b>Multi-step reaction with 5 steps<br /> </b>1: tetrabutylammomium bromide; potassium carbonate / chloroform; water / 2 h / 10 - 55 °C<br />2: 1-methyl-pyrrolidin-2-one; [Ru(COD)(Cl<sub>2</sub>)]2; triphenylphosphine / 2 h / 140 °C<br />3: methanol; sodium methylate / 1.5 h / 20 °C<br />4: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C<br />5: potassium carbonate / N,N-dimethyl acetamide / 8 h / -10 - 20 °C<br /> <br />
参考文献
Seki, Masahiko; Nagahama, Masaki Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 10198 - 10206
