1307853-71-9合成路线

1307853-71-9合成路线（共 8 条）

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反应条件

1: SnCl2·2H2O / methanol / 2 h / Reflux 2: acetic acid / 1 h / 90 °C 3: sodium hydroxide / methanol / 2 h / 90 °C 4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C 5: ammonium formate / 5 palladium on charcoal / isopropyl alcohol; water / 17 h / 40 - 50 °C View Scheme

参考文献

MITSUBISHI TANABE PHARMA CORPORATION
Patent: US2012/232283 A1, 2012 ;

1307853-69-5

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1307853-71-9

反应条件

With  <a href="#" onclick="return RXDsubstances(event, this, '1098214', constants.ctx, '0')">hydrogenchloride</a> in  <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> T=3 - 9°C; 3.21667 h;

参考文献

MITSUBISHI TANABE PHARMA CORPORATION Patent: US2012/232283 A1, 2012 ; Location in patent: Page/Page column 44 ;

98-88-4苯甲酰氯

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1307853-71-9

反应条件

Multi-step reaction with 7 steps 1.1: triethylamine / tetrahydrofuran / 7 - 16 °C 2.1: phosphorus pentachloride / dichloromethane / -11 - 19 °C 2.2: 7 h / -6 - 20 °C 3.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere 4.1: sodium methylate / methanol / 1.5 h / 20 °C 5.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C 6.1: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere 7.1: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C

参考文献

MITSUBISHI TANABE PHARMA CORPORATION Patent: US2012/232283 A1, 2012 ;

21388-92-1

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1307853-71-9

反应条件

Multi-step reaction with 5 steps 1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere 2: sodium methylate / methanol / 1.5 h / 20 °C 3: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C 4: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere 5: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C

参考文献

MITSUBISHI TANABE PHARMA CORPORATION Patent: US2012/232283 A1, 2012 ;

41882-10-4

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1307853-71-9

反应条件

Multi-step reaction with 6 steps 1.1: phosphorus pentachloride / dichloromethane / -11 - 19 °C 1.2: 7 h / -6 - 20 °C 2.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere 3.1: sodium methylate / methanol / 1.5 h / 20 °C 4.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C 5.1: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere 6.1: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C

参考文献

MITSUBISHI TANABE PHARMA CORPORATION Patent: US2012/232283 A1, 2012 ;

824-94-24-甲氧基氯苄

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1307853-71-9

反应条件

Multi-step reaction with 6 steps 1.1: sodium carbonate; tetrabutylammomium bromide / chloroform; water / 2 h / 55 °C / Cooling with ice 1.2: 1 h 2.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere 3.1: sodium methylate / methanol / 1.5 h / 20 °C 4.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C 5.1: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere 6.1: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C

参考文献

MITSUBISHI TANABE PHARMA CORPORATION Patent: US2012/232283 A1, 2012 ;

2393-23-94-甲氧基苄胺

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1307853-71-9

反应条件

参考文献

MITSUBISHI TANABE PHARMA CORPORATION Patent: US2012/232283 A1, 2012 ;

873-75-64-溴苄醇

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1307853-71-9

反应条件

Multi-step reaction with 6 steps 1: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 15 - 30 °C 2: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere 3: sodium methylate / methanol / 1.5 h / 20 °C 4: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C 5: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere 6: hydrogenchloride / methanol / 3.22 h / 3 - 9 °C

参考文献

MITSUBISHI TANABE PHARMA CORPORATION Patent: US2012/232283 A1, 2012 ;