3,3,3-三氟丙酮酸乙酯合成路线 （共 29 条）
参考文献
E. I. Du Pont de Nemours and Company
Patent: US4357282 A1, 1982 ;
反应条件
SbF5 in neat (no solvent)
参考文献
England, David C.
Journal of Organic Chemistry, 1984 , vol. 49, # 21 p. 4007 - 4008
反应条件
zinc in pyridine T=20°C; 2 h; other esters; other perfluoroalkyl iodide;
参考文献
Francese, C.; Tordeux, M.; Wakselman, C.
Tetrahedron Letters, 1988 , vol. 29, # 9 p. 1029 - 1030
反应条件
hydrogenchloride Heating;
参考文献
Gazzetta Chimica Italiana, , vol. 98, p. 265 - 276
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 19, # 8 p. 1563 - 1564
Zhurnal Organicheskoi Khimii, , vol. 19, # 8 p. 1761 - 1762
反应条件
1: With water; sodium hydroxide in ethanol T=20°C; 20 h; 2: With hydrogenchloride in water pH=1 - 2;
参考文献
SHANGHAI DE NOVO PHARMATECH CO LTD.; Gao, Daxin
Patent: US2013/224107 A1, 2013 ;
Location in patent: Paragraph 0130; 0131 ;
反应条件
in water T=50°C; 0.25 h;
参考文献
Murthy, Sabbavarapu Narayana; Madhav, Bandaru; Nageswar, Yadavalli Venkata Durga
Helvetica Chimica Acta, 2010 , vol. 93, # 6 p. 1216 - 1220
反应条件
1: 98 percent / CH2Cl2 2: 70 percent / trifluoroacetic acid anhydride, pyridine / diethyl ether / 1 h / 0 °C View Scheme
参考文献
Burger, Klaus; Hoess, Eva; Gaa, Karl; Sewald, Norbert; Schierlinger, Christian
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1991 , vol. 46, # 3 p. 361 - 384
反应条件
1: 99 percent / CH2Cl2 / 2 h / Ambient temperature 2: 58 percent / trifluoroacetic acid anhydride, pyridine / diethyl ether / 1 h / 0 °C View Scheme
参考文献
Burger, Klaus; Hoess, Eva; Gaa, Karl; Sewald, Norbert; Schierlinger, Christian
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1991 , vol. 46, # 3 p. 361 - 384
反应条件
1: (CF3CO)2O; pyridine View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 5 p. 1808 - 1817
