3,3,3-三氟丙酮酸乙酯合成路线 （共 29 条）
反应条件
1: trifluoro-pyruvic acid ethyl ester; ethylmagnesium bromide
2: With hydrazine
Heating;
3: bromocyane With potassium hydrogencarbonate in water
参考文献
Ducharme, Yves; Blouin, Marc; Brideau, Christine; Chateauneuf, Anne; Gareau, Yves; Grimm, Erich L.; Juteau, Helene; Laliberte, Sebastien; MacKay, Bruce; Masse, Frederic; Ouellet, Marc; Salem, Myriam; Styhler, Angela; Friesen, Richard W.
ACS Medicinal Chemistry Letters, 2010 , vol. 1, # 4 p. 170 - 174
反应条件
sodium tetrahydroborate in diethyl ether
a) ice-cooling, 15 min, b) r.t., 3 h;
参考文献
Bussche-Huennefeld, Christoph von .; Cescato, Claudio; Seebach, Dieter
Chemische Berichte, 1992 , vol. 125, # 12 p. 2795 - 2802
反应条件
1: ethyl magnesium chloride With diethylzinc; (R)-2,2'-dihydroxy-1,1'-binaphthyl in tetrahydrofuran; 1,2-dichloro-ethane
T=-40 - 20°C; 1 h;
2: trifluoro-pyruvic acid ethyl ester in tetrahydrofuran; 1,2-dichloro-ethane
T=-40°C; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Gosselin, Francis; Britton, Robert A.; Mowat, Jeffrey; O'Shea, Paul D.; Davies, Ian W.
Synlett, 2007 , # 14 p. 2193 - 2196
反应条件
1: n-propyl-magnesium chloride With diethylzinc; (R)-2,2'-dihydroxy-1,1'-binaphthyl in tetrahydrofuran; 1,2-dichloro-ethane
T=-40 - 20°C; 1 h;
2: trifluoro-pyruvic acid ethyl ester in tetrahydrofuran; 1,2-dichloro-ethane
T=-40°C; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Gosselin, Francis; Britton, Robert A.; Mowat, Jeffrey; O'Shea, Paul D.; Davies, Ian W.
Synlett, 2007 , # 14 p. 2193 - 2196
反应条件
1: n-butyl-magnesium chloride With diethylzinc; (R)-2,2'-dihydroxy-1,1'-binaphthyl in tetrahydrofuran; 1,2-dichloro-ethane
T=-40 - 20°C; 1 h;
2: trifluoro-pyruvic acid ethyl ester in tetrahydrofuran; 1,2-dichloro-ethane
T=-40°C; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Gosselin, Francis; Britton, Robert A.; Mowat, Jeffrey; O'Shea, Paul D.; Davies, Ian W.
Synlett, 2007 , # 14 p. 2193 - 2196
反应条件
1: n-pentylmagnesium chloride With diethylzinc; (R)-2,2'-dihydroxy-1,1'-binaphthyl in tetrahydrofuran; 1,2-dichloro-ethane
T=-40 - 20°C; 1 h;
2: trifluoro-pyruvic acid ethyl ester in tetrahydrofuran; 1,2-dichloro-ethane
T=-40°C; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Gosselin, Francis; Britton, Robert A.; Mowat, Jeffrey; O'Shea, Paul D.; Davies, Ian W.
Synlett, 2007 , # 14 p. 2193 - 2196
反应条件
1: phenyl-magnesium chloride With diethylzinc; (R)-2,2'-dihydroxy-1,1'-binaphthyl in tetrahydrofuran; 1,2-dichloro-ethane
T=-40 - 20°C; 1 h;
2: trifluoro-pyruvic acid ethyl ester in tetrahydrofuran; 1,2-dichloro-ethane
T=-40°C; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Gosselin, Francis; Britton, Robert A.; Mowat, Jeffrey; O'Shea, Paul D.; Davies, Ian W.
Synlett, 2007 , # 14 p. 2193 - 2196
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
RefluxCooling with ice;
参考文献
Wang; Lee; Li; Yang; Huang
Electrochemistry Communications, 2010 , vol. 12, # 3 p. 386 - 389
反应条件
pyridine; toluene-4-sulfonic acid hydrazide; trichlorophosphate
1) CH2Cl2, a) reflux, b) RT, overnight, 2) 20 min, reflux; Yield given. Multistep reaction;
参考文献
Shi, Guoqiang; Xu, Yuanyao
Journal of the Chemical Society, Chemical Communications, 1989 , # 10 p. 607 - 608
