sodium hydroxide in tetrahydrofuran; water 0.833333 h;

1: 98 percent / pyridine / CHCl3 / 72 h / Ambient temperature 2: 66 percent / dimethylsulfoxide / 4 h / 80 °C 3: 94 percent / HCl / 84 h / Ambient temperature 4: 97 percent / 4 M NaOH / tetrahydrofuran; H2O / 0.83 h View Scheme

1: 94 percent / HCl / 84 h / Ambient temperature 2: 97 percent / 4 M NaOH / tetrahydrofuran; H2O / 0.83 h View Scheme

1: 66 percent / dimethylsulfoxide / 4 h / 80 °C 2: 94 percent / HCl / 84 h / Ambient temperature 3: 97 percent / 4 M NaOH / tetrahydrofuran; H2O / 0.83 h View Scheme

1: 98 percent / NaHCO3 / H2O; toluene / 16 h / Ambient temperature 2: 100 percent / p-toluenesulfonic acid / ethanol / 16 h / Heating 3: 98 percent / pyridine / CHCl3 / 72 h / Ambient temperature 4: 66 percent / dimethylsulfoxide / 4 h / 80 °C 5: 94 percent / HCl / 84 h / Ambient temperature 6: 97 percent / 4 M NaOH / tetrahydrofuran; H2O / 0.83 h View Scheme

1: 98 percent / NaHCO3 / H2O; toluene / 16 h / Ambient temperature 2: 100 percent / p-toluenesulfonic acid / ethanol / 16 h / Heating 3: 98 percent / pyridine / CHCl3 / 72 h / Ambient temperature 4: 66 percent / dimethylsulfoxide / 4 h / 80 °C 5: 94 percent / HCl / 84 h / Ambient temperature 6: 97 percent / 4 M NaOH / tetrahydrofuran; H2O / 0.83 h View Scheme

1: 100 percent / p-toluenesulfonic acid / ethanol / 16 h / Heating 2: 98 percent / pyridine / CHCl3 / 72 h / Ambient temperature 3: 66 percent / dimethylsulfoxide / 4 h / 80 °C 4: 94 percent / HCl / 84 h / Ambient temperature 5: 97 percent / 4 M NaOH / tetrahydrofuran; H2O / 0.83 h View Scheme

Pd-C in methanol